Search Results

Overview

Uniprot IDQ149N8
Protein NameE3 ubiquitin-protein ligase SHPRH
Gene NameSHPRH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1572 QENLSAFKRDPQINI

Function

E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'

Protein Sequence

10 MSSRRKRAPP 20 VRVDEEKRQQ 30 LHWNMHEDRR 40 NEPIIISDDD 50 EQPCPGSDTS 60 SAHYIILSDS 70 LKEEVAHRDK 80 KRCSKVVSFS 90 KPIEKEETVG 100 IFSPLSVKLN 110 IVISPYHFDN 120 SWKAFLGELT 130 LQLLPAQSLI 140 ENFSERSITL 150 MSSESSNQFL 160 IYVHSKGEDV 170 EKQKKEPMSI 180 CDKGILVESS 190 FSGEMLEDLG 200 WLQKKRRIKL 210 YQKPEGNHII 220 KVGIYLLEAG 230 LAKLDFLSDA 240 NSRMKKFNQL 250 MKKVMEKLHN 260 SIIPDVLEED 270 EDDPESEPEG 280 QDIDELYHFV 290 KQTHQQETQS 300 IQVDVQHPAL 310 IPVLRPYQRE 320 AVNWMLQQEC 330 FRSSPATESA 340 LHFLWREIVT 350 SEGLKLYYNP 360 YTGCIIREYP 370 NSGPQLLGGI 380 LADEMGLGKT 390 VEVLALILTH 400 TRQDVKQDAL 410 TLPEGKVVNY 420 FIPSHYFGGK 430 LKKTEIQNIE 440 FEPKEKVQCP 450 PTRVMILTAV 460 KEMNGKKGVS 470 ILSIYKYVSS 480 IYRYDVQRNR 490 SLLKRMLKCL 500 IFEGLVKQIK 510 GHGFSGTFTL 520 GKNYKEEDIC 530 DKTKKQAVGS 540 PRKIQKETRK 550 SGNKDTDSEY 560 LPSDTSDDDD 570 DPYYYYYKSR 580 RNRSKLRKKL 590 VPSTKKGKSQ 600 PFINPDSQGH 610 CPATSDSGIT 620 DVAMSKSTCI 630 SEFNQEHETE 640 DCAESLNHAD 650 SDVPPSNTMS 660 PFNTSDYRFE 670 CICGELDQID 680 RKPRVQCLKC 690 HLWQHAKCVN 700 YDEKNLKIKP 710 FYCPHCLVAM 720 EPVSTRATLI 730 ISPSSICHQW 740 VDEINRHVRS 750 SSLRVLVYQG 760 VKKDGFLQPH 770 FLAEQDIVII 780 TYDVLRSELN 790 YVDIPHSNSE 800 DGRRLRNQKR 810 YMAIPSPLVA 820 VEWWRICLDE 830 AQMVECPTVK 840 AAEMAQRLSG 850 INRWCISGTP 860 VQRGLEDLFG 870 LVVFLGIEPY 880 CVKHWWVRLL 890 YRPYCKKNPQ 900 HLYSFIAKIL 910 WRSAKKDVID 920 QIQIPPQTEE 930 IHWLHFSPVE 940 RHFYHRQHEV 950 CCQDVVVKLR 960 KISDWALKLS 970 SLDRRTVTSI 980 LYPLLRLRQA 990 CCHPQAVRGE 1000 FLPLQKSTMT 1010 MEELLTSLQK 1020 KCGTECEEAH 1030 RQLVCALNGL 1040 AGIHIIKGEY 1050 ALAAELYREV 1060 LRSSEEHKGK 1070 LKTDSLQRLH 1080 ATHNLMELLI 1090 ARHPGIPPTL 1100 RDGRLEEEAK 1110 QLREHYMSKC 1120 NTEVAEAQQA 1130 LYPVQQTIHE 1140 LQRKIHSNSP 1150 WWLNVIHRAI 1160 EFTIDEELVQ 1170 RVRNEITSNY 1180 KQQTGKLSMS 1190 EKFRDCRGLQ 1200 FLLTTQMEEL 1210 NKCQKLVREA 1220 VKNLEGPPSR 1230 NVIESATVCH 1240 LRPARLPLNC 1250 CVFCKADELF 1260 TEYESKLFSN 1270 TVKGQTAIFE 1280 EMIEDEEGLV 1290 DDRAPTTTRG 1300 LWAISETERS 1310 MKAILSFAKS 1320 HRFDVEFVDE 1330 GSTSMDLFEA 1340 WKKEYKLLHE 1350 YWMALRNRVS 1360 AVDELAMATE 1370 RLRVRDPREP 1380 KPNPPVLHII 1390 EPHEVEQNRI 1400 KLLNDKAVAT 1410 SQLQKKLGQL 1420 LYLTNLEKSQ 1430 DKTSGGVNPE 1440 PCPICARQLG 1450 KQWAVLTCGH 1460 CFCNECISII 1470 IEQYSVGSHR 1480 SSIKCAICRQ 1490 TTSHKEISYV 1500 FTSEKANQEE 1510 DIPVKGSHST 1520 KVEAVVRTLM 1530 KIQLRDPGAK 1540 ALVFSTWQDV 1550 LDIISKALTD 1560 NNMEFAQISR 1570 VKTFQENLSA 1580 FKRDPQINIL 1590 LLPLHTGSNG 1600 LTIIEATHVL 1610 LVEPILNPAH 1620 ELQAIGRVHR 1630 IGQTKPTIVH 1640 RFLIKATIEE 1650 RMQAMLKTAE 1660 RSHTNSSAKH 1670 SEASVLTVAD 1680 LADLFTKETE ELE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0000786 nucleosome
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0004386 helicase activity
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Molecular Function GO:0004842 ubiquitin-protein transferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006281 DNA repair
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0016567 protein ubiquitination

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.