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Overview

Uniprot IDQ14C86
Protein NameGTPase-activating protein and VPS9 domain-containing protein 1
Gene NameGAPVD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
988 RFVSAMPKAPIPFRK

Function

Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras

Protein Sequence

10 MVKLDIHTLA 20 HHLKQERLYV 30 NSEKQLIQRL 40 NADVLKTAEK 50 LYRTAWIAKQ 60 QRINLDRLII 70 TSAEASPAEC 80 CQHAKILEDT 90 QFVDGYKQLG 100 FQETAYGEFL 110 SRLRENPRLI 120 ASSLVAGEKL 130 NQENTQSVIY 140 TVFTSLYGNC 150 IMQEDESYLL 160 QVLRYLIEFE 170 LKESDNPRRL 180 LRRGTCAFSI 190 LFKLFSEGLF 200 SAKLFLTATL 210 HEPIMQLLVE 220 DEDHLETDPN 230 KLIERFSPSQ 240 QEKLFGEKGS 250 DRFRQKVQEM 260 VESNEAKLVA 270 LVNKFIGYLK 280 QNTYCFPHSL 290 RWIVSQMYKT 300 LSCVDRLEVG 310 EVRAMCTDLL 320 LACFICPAVV 330 NPEQYGIISD 340 APINEVARFN 350 LMQVGRLLQQ 360 LAMTGSEEGD 370 PRTKSSLGKF 380 DKSCVAAFLD 390 VVIGGRAVET 400 PPLSSVNLLE 410 GLSRTVVYIT 420 YSQLITLVNF 430 MKSVMSGDQL 440 REDRMALDNL 450 LANLPPAKPG 460 KSSSLEMTPY 470 NTPQLSPATT 480 PANKKNRLPI 490 ATRSRSRTNM 500 LMDLHMDHEG 510 SSQETIQEVQ 520 PEEVLVISLG 530 TGPQLTPGMM 540 SENEVLNMQL 550 SDGGQGDVPV 560 DENKLHGKPD 570 KTLRFSLCSD 580 NLEGISEGPS 590 NRSNSVSSLD 600 LEGESVSELG 610 AGPSGSNGVE 620 ALQLLEHEQA 630 TTQDNLDDKL 640 RKFEIRDMMG 650 LTDDRDISET 660 VSETWSTDVL 670 GSDFDPNIDE 680 DRLQEIAGAA 690 AENMLGSLLC 700 LPGSGSVLLD 710 PCTGSTISET 720 TSEAWSVEVL 730 PSDSEAPDLK 740 QEERLQELES 750 CSGLGSTSDD 760 TDVREVSSRP 770 STPGLSVVSG 780 ISATSEDIPN 790 KIEDLRSECS 800 SDFGGKDSVT 810 SPDMDEITHG 820 AHQLTSPPSQ 830 SESLLAMFDP 840 LSSHEGASAV 850 VRPKVHYARP 860 SHPPPDPPIL 870 EGAVGGNEAR 880 LPNFGSHVLT 890 PAEMEAFKQR 900 HSYPERLVRS 910 RSSDIVSSVR 920 RPMSDPSWNR 930 RPGNEERELP 940 PAAAIGATSL 950 VAAPHSSSSS 960 PSKDSSRGET 970 EERKDSDDEK 980 SDRNRPWWRK 990 RFVSAMPKAP 1000 IPFRKKEKQE 1010 KDKDDLGPDR 1020 FSTLTDDPSP 1030 RLSAQAQVAE 1040 DILDKYRNAI 1050 KRTSPSDGAM 1060 ANYESTGDNH 1070 DRDLSSKLLY 1080 HSDKEVMGDG 1090 ESAHDSPRDE 1100 ALQNISADDL 1110 PDSASQAAHP 1120 QDSAFSYRDA 1130 KKKLRLALCS 1140 ADSVAFPVLT 1150 HSTRNGLPDH 1160 TDPEDNEIVC 1170 FLKVQIAEAI 1180 NLQDKNLMAQ 1190 LQETMRCVCR 1200 FDNRTCRKLL 1210 ASIAEDYRKR 1220 APYIAYLTRC 1230 RQGLQTTQAH 1240 LERLLQRVLR 1250 DKEVANRYFT 1260 TVCVRLLLES 1270 KEKKIREFIQ 1280 DFQKLTAADD 1290 KTAQVEDFLQ 1300 FLYGAMAQDV 1310 IWQNASEEQL 1320 QDAQLAIERS 1330 VMNRIFKLAF 1340 YPNQDGDILR 1350 DQVLHEHIQR 1360 LSKVVTANHR 1370 ALQIPEVYLR 1380 EAPWPSAQSE 1390 IRTISAYKTP 1400 RDKVQCILRM 1410 CSTIMNLLSL 1420 ANEDSVPGAD 1430 DFVPVLVFVL 1440 IKANPPCLLS 1450 TVQYISSFYA 1460 SCLSGEESYW 1470 WMQFTAAVEF IKTIDDRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005768 endosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0032794 GTPase activating protein binding
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0051223 regulation of protein transport

Reference

PMID: N/A