Search Results
Overview
| Uniprot ID | Q14CB8 |
|---|---|
| Protein Name | Rho GTPase-activating protein 19 |
| Gene Name | ARHGAP19 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 255 | DLLYQTAKKQDKNKM |
Function
Has GTPase activator activity toward RHOA; RHOA activation results in GTP hydrolysis and conversion from an active GTP-bound to an inactive GDP-bound state (PubMed:24259668, PubMed:41086021). Lacks GTPase activator activity toward RAC1 or CDC42 (PubMed:24259668)
Protein Sequence
10
MATEAQSEGE
20
VPARESGRSD
30
AICSFVICND
40
SSLRGQPIIF
50
NPDFFVEKLR
60
HEKPEIFTEL
70
VVSNITRLID
80
LPGTELAQLM
90
GEVDLKLPGG
100
AGPASGFFRS
110
LMSLKRKEKG
120
VIFGSPLTEE
130
GIAQIYQLIE
140
YLHKNLRVEG
150
LFRVPGNSVR
160
QQILRDALNN
170
GTDIDLESGE
180
FHSNDVATLL
190
KMFLGELPEP
200
LLTHKHFNAH
210
LKIADLMQFD
220
DKGNKTNIPD
230
KDRQIEALQL
240
LFLILPPPNR
250
NLLKLLLDLL
260
YQTAKKQDKN
270
KMSAYNLALM
280
FAPHVLWPKN
290
VTANDLQENI
300
TKLNSGMAFM
310
IKHSQKLFKA
320
PAYIRECARL
330
HYLGSRTQAS
340
KDDLDLIASC
350
HTKSFQLAKS
360
QKRNRVDSCP
370
HQEETQHHTE
380
EALRELFQHV
390
HDMPESAKKK
400
QLIRQFNKQS
410
LTQTPGREPS
420
TSQVQKRARS
430
RSFSGLIKRK
440
VLGNQMMSEK
450
KKKNPTPESV
460
AIGELKGTSK
470
ENRNLLFSGS
480
PAVTMTPTRL
490
KWSEGKKEGK
KGFL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Biological Process | GO:0051056 | regulation of small GTPase mediated signal transduction |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.