Overview
| Uniprot ID | Q14CW9 |
|---|
| Protein Name | Ataxin-7-like protein 3 |
|---|
| Gene Name | ATXN7L3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 328 |
ASGLGSNKKKKPKPP |
| 329 |
SGLGSNKKKKPKPPA |
Function
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583)
Protein Sequence
10
MKMEEMSLSG
20
LDNSKLEAIA
30
QEIYADLVED
40
SCLGFCFEVH
50
RAVKCGYFFL
60
DDTDPDSMKD
70
FEIVDQPGLD
80
IFGQVFNQWK
90
SKECVCPNCS
100
RSIAASRFAP
110
HLEKCLGMGR
120
NSSRIANRRI
130
ANSNNMNKSE
140
SDQEDNDDIN
150
DNDWSYGSEK
160
KAKKRKSDKN
170
PNSPRRSKSL
180
KHKNGELSNS
190
DPFKYNNSTG
200
ISYETLGPEE
210
LRSLLTTQCG
220
VISEHTKKMC
230
TRSLRCPQHT
240
DEQRRTVRIY
250
FLGPSAVLPE
260
VESSLDNDSF
270
DMTDSQALIS
280
RLQWDGSSDL
290
SPSDSGSSKT
300
SENQGWGLGT
310
NSSESRKTKK
320
KKSHLSLVGT
330
ASGLGSNKKK
340
KPKPPAPPTP
SIYDDIN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071819 |
DUBm complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000124 |
SAGA complex |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0006282 |
regulation of DNA repair |
| Biological Process |
GO:0043484 |
regulation of RNA splicing |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
PMID: N/A