Search Results

Overview

Uniprot ID	Q14CZ7
Protein Name	FAST kinase domain-containing protein 3, mitochondrial
Gene Name	FASTKD3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
402	TFVCQTEKFSPRQIS

Function

Required for normal mitochondrial respiration (PubMed:20869947). Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity (PubMed:27789713)

Protein Sequence

10 MALITLRKNL 20 YRLSDFQMHR 30 ALAALKNKPL 40 NHVHKVVKER 50 LCPWLCSRQP 60 EPFGVKFHHA 70 HCKKFHSKNG 80 NDLHPLGGPV 90 FSQVSDCDRL 100 EQNVKNEESQ 110 MFYRRLSNLT 120 SSEEVLSFIS 130 TMETLPDTMA 140 AGALQRICEV 150 EKKDGDQGLP 160 KEILENSIFQ 170 ALCFQFEKEP 180 SQLSNTSLVT 190 ALQALILLHV 200 DPQSSLLLNL 210 VAECQNRLRK 220 GGMEVRNLCI 230 LGESLITLHS 240 SGCVTLELII 250 NQLQGEKLET 260 FTPEDIVALY 270 RILQACTEKV 280 DEHQTFLNKI 290 NNFSLSIVSN 300 LSPKLISQML 310 TALVVLDQSQ 320 AFPLIIKLGK 330 YVVRHVPHFT 340 NEELRRVLEA 350 FIYFGHHDTF 360 FTKALEHRVA 370 AVCLTLDPEV 380 VCRVMEYCSR 390 ELILSKPILN 400 AVAETFVCQT 410 EKFSPRQISA 420 LMEPFGKLNY 430 LPPNASALFR 440 KLENVLFTHF 450 NYFPPKSLLK 460 LLHSCSLNEC 470 HPVNFLAKIF 480 KPLFLQRLQG 490 KESHLDTLSR 500 AQLTQLFLAS 510 VLECPFYKGP 520 KLLPKYQVKS 530 FLTPCCSLET 540 PVDSQLYRYV 550 KIGLTNLLGA 560 RLYFAPKVLT 570 PYCYTIDVEI 580 KLDEEGFVLP 590 STANEDIHKR 600 IALCIDGPKR 610 FCSNSKHLLG 620 KEAIKQRHLQ 630 LLGYQVVQIP 640 YHEIGMLKSR 650 RELVEYLQRK 660 LFSQNTVHWL QE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Biological Process	GO:0033617	mitochondrial respiratory chain complex IV assembly
Biological Process	GO:0000963	mitochondrial RNA processing
Biological Process	GO:0070131	positive regulation of mitochondrial translation
Biological Process	GO:0044528	regulation of mitochondrial mRNA stability
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0035770	ribonucleoprotein granule
Molecular Function	GO:0003723	RNA binding

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.