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Overview

Uniprot IDQ15003
Protein NameCondensin complex subunit 2
Gene NameNCAPH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
185 RVLGGLGKDAPSLEE
488 DVYFRKTKAATILTK
630 AEPQKVNKIEIHYAK
674 ANHREAGKEAALAEV

Function

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959)

Protein Sequence

10 MGPPGPALPA 20 TMNNSSSETR 30 GHPHSASSPS 40 ERVFPMPLPR 50 KAPLNIPGTP 60 VLEDFPQNDD 70 EKERLQRRRS 80 RVFDLQFSTD 90 SPRLLASPSS 100 RSIDISATIP 110 KFTNTQITEH 120 YSTCIKLSTE 130 NKITTKNAFG 140 LHLIDFMSEI 150 LKQKDTEPTN 160 FKVAAGTLDA 170 STKIYAVRVD 180 AVHADVYRVL 190 GGLGKDAPSL 200 EEVEGHVADG 210 SATEMGTTKK 220 AVKPKKKHLH 230 RTIEQNINNL 240 NVSEADRKCE 250 IDPMFQKTAA 260 SFDECSTAGV 270 FLSTLHCQDY 280 RSELLFPSDV 290 QTLSTGEPLE 300 LPELGCVEMT 310 DLKAPLQQCA 320 EDRQICPSLA 330 GFQFTQWDSE 340 THNESVSALV 350 DKFKKNDQVF 360 DINAEVDESD 370 CGDFPDGSLG 380 DDFDANDEPD 390 HTAVGDHEEF 400 RSWKEPCQVQ 410 SCQEEMISLG 420 DGDIRTMCPL 430 LSMKPGEYSY 440 FSPRTMSMWA 450 GPDHWRFRPR 460 RKQDAPSQSE 470 NKKKSTKKDF 480 EIDFEDDIDF 490 DVYFRKTKAA 500 TILTKSTLEN 510 QNWRATTLPT 520 DFNYNVDTLV 530 QLHLKPGTRL 540 LKMAQGHRVE 550 TEHYEEIEDY 560 DYNNPNDTSN 570 FCPGLQAADS 580 DDEDLDDLFV 590 GPVGNSDLSP 600 YPCHPPKTAQ 610 QNGDTPEAQG 620 LDITTYGESN 630 LVAEPQKVNK 640 IEIHYAKTAK 650 KMDMKKLKQS 660 MWSLLTALSG 670 KEADAEANHR 680 EAGKEAALAE 690 VADEKMLSGL 700 TKDLQRSLPP 710 VMAQNLSIPL 720 AFACLLHLAN 730 EKNLKLEGTE 740 DLSDVLVRQG D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0000796 condensin complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003682 chromatin binding
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0051301 cell division
Biological Process GO:0051309 female meiosis chromosome separation
Biological Process GO:0071707 immunoglobulin heavy chain V-D-J recombination
Biological Process GO:0007076 mitotic chromosome condensation
Biological Process GO:1905821 positive regulation of chromosome condensation
Biological Process GO:0051984 positive regulation of chromosome segregation
Biological Process GO:1905820 positive regulation of chromosome separation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.