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Overview

Uniprot ID	Q15004
Protein Name	PCNA-associated factor
Gene Name	PCLAF
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
24	VAARAPRKVLGSSTS
5	***MVRTKADSVPGT
60	VCVRPTPKWQKGIGE
63	RPTPKWQKGIGEFFR
93	AGSSGLGKAKRKACP
95	SSGLGKAKRKACPLQ
97	GLGKAKRKACPLQPD

Function

PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number

Protein Sequence

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0060090	molecular adaptor activity
Biological Process	GO:0007098	centrosome cycle
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0006260	DNA replication
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0009411	response to UV
Biological Process	GO:0019985	translesion synthesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.