Search Results
Overview
| Uniprot ID | Q15005 |
|---|---|
| Protein Name | Signal peptidase complex subunit 2 |
| Gene Name | SPCS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 65 | NSLDDSAKKVLLEKY |
Function
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity)
Protein Sequence
10
MAAAAVQGGR
20
SGGSGGCSGA
30
GGASNCGTGS
40
GRSGLLDKWK
50
IDDKPVKIDK
60
WDGSAVKNSL
70
DDSAKKVLLE
80
KYKYVENFGL
90
IDGRLTICTI
100
SCFFAIVALI
110
WDYMHPFPES
120
KPVLALCVIS
130
YFVMMGILTI
140
YTSYKEKSIF
150
LVAHRKDPTG
160
MDPDDIWQLS
170
SSLKRFDDKY
180
TLKLTFISGR
190
TKQQREAEFT
200
KSIAKFFDHS
210
GTLVMDAYEP
220
EISRLHDSLA
IERKIK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005787 | signal peptidase complex |
| Biological Process | GO:0045047 | protein targeting to ER |
| Biological Process | GO:0006465 | signal peptide processing |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.