Overview
| Uniprot ID | Q15007 |
|---|
| Protein Name | Pre-mRNA-splicing regulator WTAP |
|---|
| Gene Name | WTAP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 268 |
EQSEATSKDCSRLTN |
| 371 |
EEKAVSGKGNRTVGS |
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724)
Protein Sequence
10
MTNEEPLPKK
20
VRLSETDFKV
30
MARDELILRW
40
KQYEAYVQAL
50
EGKYTDLNSN
60
DVTGLRESEE
70
KLKQQQQESA
80
RRENILVMRL
90
ATKEQEMQEC
100
TTQIQYLKQV
110
QQPSVAQLRS
120
TMVDPAINLF
130
FLKMKGELEQ
140
TKDKLEQAQN
150
ELSAWKFTPD
160
SQTGKKLMAK
170
CRMLIQENQE
180
LGRQLSQGRI
190
AQLEAELALQ
200
KKYSEELKSS
210
QDELNDFIIQ
220
LDEEVEGMQS
230
TILVLQQQLK
240
ETRQQLAQYQ
250
QQQSQASAPS
260
TSRTTASEPV
270
EQSEATSKDC
280
SRLTNGPSNG
290
SSSRQRTSGS
300
GFHREGNTTE
310
DDFPSSPGNG
320
NKSSNSSEER
330
TGRGGSGYVN
340
QLSAGYESVD
350
SPTGSENSLT
360
HQSNDTDSSH
370
DPQEEKAVSG
380
KGNRTVGSRH
390
VQNGLDSSVN
VQGSVL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0036396 |
RNA N6-methyladenosine methyltransferase complex |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Biological Process |
GO:0016556 |
mRNA modification |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.