Search Results

Overview

Uniprot ID	Q15008
Protein Name	26S proteasome non-ATPase regulatory subunit 6
Gene Name	PSMD6
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
130	AFRKTYDKTVALGHR
372	QYQETIKKGDLLLNR

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MPLENLEEEG 20 LPKNPDLRIA 30 QLRFLLSLPE 40 HRGDAAVRDE 50 LMAAVRDNNM 60 APYYEALCKS 70 LDWQIDVDLL 80 NKMKKANEDE 90 LKRLDEELED 100 AEKNLGESEI 110 RDAMMAKAEY 120 LCRIGDKEGA 130 LTAFRKTYDK 140 TVALGHRLDI 150 VFYLLRIGLF 160 YMDNDLITRN 170 TEKAKSLIEE 180 GGDWDRRNRL 190 KVYQGLYCVA 200 IRDFKQAAEL 210 FLDTVSTFTS 220 YELMDYKTFV 230 TYTVYVSMIA 240 LERPDLREKV 250 IKGAEILEVL 260 HSLPAVRQYL 270 FSLYECRYSV 280 FFQSLAVVEQ 290 EMKKDWLFAP 300 HYRYYVREMR 310 IHAYSQLLES 320 YRSLTLGYMA 330 EAFGVGVEFI 340 DQELSRFIAA 350 GRLHCKIDKV 360 NEIVETNRPD 370 SKNWQYQETI 380 KKGDLLLNRV QKLSRVINM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0022624	proteasome accessory complex
Cellular Component	GO:0000502	proteasome complex
Cellular Component	GO:0005838	proteasome regulatory particle
Cellular Component	GO:0034774	secretory granule lumen
Cellular Component	GO:0008021	synaptic vesicle
Biological Process	GO:0071357	cellular response to type I interferon
Biological Process	GO:0010498	proteasomal protein catabolic process
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process
Biological Process	GO:0006979	response to oxidative stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.