Search Results

Overview

Uniprot IDQ15021
Protein NameCondensin complex subunit 1
Gene NameNCAPD2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1201 LSYITKDKQTESLVE
1387 TEDETPKKTTPILRA
155 KGKKARTKAAHGFDW
395 FTRIVQQKALPLTRF
531 LAKASYKKAIILTRE
597 VTGQTVCKNKPNMSD
599 GQTVCKNKPNMSDPE
705 RQLYLNPKGDSARAK

Function

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959)

Protein Sequence

10 MAPQMYEFHL 20 PLSPEELLKS 30 GGVNQYVVQE 40 VLSIKHLPPQ 50 LRAFQAAFRA 60 QGPLAMLQHF 70 DTIYSILHHF 80 RSIDPGLKED 90 TLQFLIKVVS 100 RHSQELPAIL 110 DDTTLSGSDR 120 NAHLNALKMN 130 CYALIRLLES 140 FETMASQTNL 150 VDLDLGGKGK 160 KARTKAAHGF 170 DWEEERQPIL 180 QLLTQLLQLD 190 IRHLWNHSII 200 EEEFVSLVTG 210 CCYRLLENPT 220 INHQKNRPTR 230 EAITHLLGVA 240 LTRYNHMLSA 250 TVKIIQMLQH 260 FEHLAPVLVA 270 AVSLWATDYG 280 MKSIVGEIVR 290 EIGQKCPQEL 300 SRDPSGTKGF 310 AAFLTELAER 320 VPAILMSSMC 330 ILLDHLDGEN 340 YMMRNAVLAA 350 MAEMVLQVLS 360 GDQLEAAARD 370 TRDQFLDTLQ 380 AHGHDVNSFV 390 RSRVLQLFTR 400 IVQQKALPLT 410 RFQAVVALAV 420 GRLADKSVLV 430 CKNAIQLLAS 440 FLANNPFSCK 450 LSDADLAGPL 460 QKETQKLQEM 470 RAQRRTAAAS 480 AVLDPEEEWE 490 AMLPELKSTL 500 QQLLQLPQGE 510 EEIPEQIANT 520 ETTEDVKGRI 530 YQLLAKASYK 540 KAIILTREAT 550 GHFQESEPFS 560 HIDPEESEET 570 RLLNILGLIF 580 KGPAASTQEK 590 NPRESTGNMV 600 TGQTVCKNKP 610 NMSDPEESRG 620 NDELVKQEML 630 VQYLQDAYSF 640 SRKITEAIGI 650 ISKMMYENTT 660 TVVQEVIEFF 670 VMVFQFGVPQ 680 ALFGVRRMLP 690 LIWSKEPGVR 700 EAVLNAYRQL 710 YLNPKGDSAR 720 AKAQALIQNL 730 SLLLVDASVG 740 TIQCLEEILC 750 EFVQKDELKP 760 AVTQLLWERA 770 TEKVACCPLE 780 RCSSVMLLGM 790 MARGKPEIVG 800 SNLDTLVSIG 810 LDEKFPQDYR 820 LAQQVCHAIA 830 NISDRRKPSL 840 GKRHPPFRLP 850 QEHRLFERLR 860 ETVTKGFVHP 870 DPLWIPFKEV 880 AVTLIYQLAE 890 GPEVICAQIL 900 QGCAKQALEK 910 LEEKRTSQED 920 PKESPAMLPT 930 FLLMNLLSLA 940 GDVALQQLVH 950 LEQAVSGELC 960 RRRVLREEQE 970 HKTKDPKEKN 980 TSSETTMEEE 990 LGLVGATADD 1000 TEAELIRGIC 1010 EMELLDGKQT 1020 LAAFVPLLLK 1030 VCNNPGLYSN 1040 PDLSAAASLA 1050 LGKFCMISAT 1060 FCDSQLRLLF 1070 TMLEKSPLPI 1080 VRSNLMVATG 1090 DLAIRFPNLV 1100 DPWTPHLYAR 1110 LRDPAQQVRK 1120 TAGLVMTHLI 1130 LKDMVKVKGQ 1140 VSEMAVLLID 1150 PEPQIAALAK 1160 NFFNELSHKG 1170 NAIYNLLPDI 1180 ISRLSDPELG 1190 VEEEPFHTIM 1200 KQLLSYITKD 1210 KQTESLVEKL 1220 CQRFRTSRTE 1230 RQQRDLAYCV 1240 SQLPLTERGL 1250 RKMLDNFDCF 1260 GDKLSDESIF 1270 SAFLSVVGKL 1280 RRGAKPEGKA 1290 IIDEFEQKLR 1300 ACHTRGLDGI 1310 KELEIGQAGS 1320 QRAPSAKKPS 1330 TGSRYQPLAS 1340 TASDNDFVTP 1350 EPRRTTRRHP 1360 NTQQRASKKK 1370 PKVVFSSDES 1380 SEEDLSAEMT 1390 EDETPKKTTP 1400 ILRASARRHR S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000793 condensed chromosome
Cellular Component GO:0000779 condensed chromosome, centromeric region
Cellular Component GO:0000796 condensin complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042393 histone binding
Biological Process GO:0051301 cell division
Biological Process GO:0010032 meiotic chromosome condensation
Biological Process GO:0007076 mitotic chromosome condensation
Biological Process GO:1905821 positive regulation of chromosome condensation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.