Search Results

Overview

Uniprot IDQ15022
Protein NamePolycomb protein SUZ12
Gene NameSUZ12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
197 KVCHKKRKDVSCPIR
5 ***MAPQKHGGGGGG
732 DSVSGVSKQSKKQKL
735 SGVSKQSKKQKL***

Function

Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557)

Protein Sequence

10 MAPQKHGGGG 20 GGGSGPSAGS 30 GGGGFGGSAA 40 VAAATASGGK 50 SGGGSCGGGG 60 SYSASSSSSA 70 AAAAGAAVLP 80 VKKPKMEHVQ 90 ADHELFLQAF 100 EKPTQIYRFL 110 RTRNLIAPIF 120 LHRTLTYMSH 130 RNSRTNIKRK 140 TFKVDDMLSK 150 VEKMKGEQES 160 HSLSAHLQLT 170 FTGFFHKNDK 180 PSPNSENEQN 190 SVTLEVLLVK 200 VCHKKRKDVS 210 CPIRQVPTGK 220 KQVPLNPDLN 230 QTKPGNFPSL 240 AVSSNEFEPS 250 NSHMVKSYSL 260 LFRVTRPGRR 270 EFNGMINGET 280 NENIDVNEEL 290 PARRKRNRED 300 GEKTFVAQMT 310 VFDKNRRLQL 320 LDGEYEVAMQ 330 EMEECPISKK 340 RATWETILDG 350 KRLPPFETFS 360 QGPTLQFTLR 370 WTGETNDKST 380 APIAKPLATR 390 NSESLHQENK 400 PGSVKPTQTI 410 AVKESLTTDL 420 QTRKEKDTPN 430 ENRQKLRIFY 440 QFLYNNNTRQ 450 QTEARDDLHC 460 PWCTLNCRKL 470 YSLLKHLKLC 480 HSRFIFNYVY 490 HPKGARIDVS 500 INECYDGSYA 510 GNPQDIHRQP 520 GFAFSRNGPV 530 KRTPITHILV 540 CRPKRTKASM 550 SEFLESEDGE 560 VEQQRTYSSG 570 HNRLYFHSDT 580 CLPLRPQEME 590 VDSEDEKDPE 600 WLREKTITQI 610 EEFSDVNEGE 620 KEVMKLWNLH 630 VMKHGFIADN 640 QMNHACMLFV 650 ENYGQKIIKK 660 NLCRNFMLHL 670 VSMHDFNLIS 680 IMSIDKAVTK 690 LREMQQKLEK 700 GESASPANEE 710 ITEEQNGTAN 720 GFSEINSKEK 730 ALETDSVSGV SKQSKKQKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005677 chromatin silencing complex
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032993 protein-DNA complex
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0016586 RSC-type complex
Cellular Component GO:0001739 sex chromatin
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0062072 histone H3K9me2/3 reader activity
Molecular Function GO:0106222 lncRNA binding
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0001222 transcription corepressor binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0140718 facultative heterochromatin formation
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0045596 negative regulation of cell differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Cellular Component GO:0035098 ESC/E(Z) complex
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.