Search Results
Overview
| Uniprot ID | Q15029 |
|---|---|
| Protein Name | 116 kDa U5 small nuclear ribonucleoprotein component |
| Gene Name | EFTUD2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 359 | KTRKFTKKAPTSSSQ |
Function
Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:25092792, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)
Protein Sequence
10
MDTDLYDEFG
20
NYIGPELDSD
30
EDDDELGRET
40
KDLDEMDDDD
50
DDDDVGDHDD
60
DHPGMEVVLH
70
EDKKYYPTAE
80
EVYGPEVETI
90
VQEEDTQPLT
100
EPIIKPVKTK
110
KFTLMEQTLP
120
VTVYEMDFLA
130
DLMDNSELIR
140
NVTLCGHLHH
150
GKTCFVDCLI
160
EQTHPEIRKR
170
YDQDLCYTDI
180
LFTEQERGVG
190
IKSTPVTVVL
200
PDTKGKSYLF
210
NIMDTPGHVN
220
FSDEVTAGLR
230
ISDGVVLFID
240
AAEGVMLNTE
250
RLIKHAVQER
260
LAVTVCINKI
270
DRLILELKLP
280
PTDAYYKLRH
290
IVDEVNGLIS
300
MYSTDENLIL
310
SPLLGNVCFS
320
SSQYSICFTL
330
GSFAKIYADT
340
FGDINYQEFA
350
KRLWGDIYFN
360
PKTRKFTKKA
370
PTSSSQRSFV
380
EFILEPLYKI
390
LAQVVGDVDT
400
SLPRTLDELG
410
IHLTKEELKL
420
NIRPLLRLVC
430
KKFFGEFTGF
440
VDMCVQHIPS
450
PKVGAKPKIE
460
HTYTGGVDSD
470
LGEAMSDCDP
480
DGPLMCHTTK
490
MYSTDDGVQF
500
HAFGRVLSGT
510
IHAGQPVKVL
520
GENYTLEDEE
530
DSQICTVGRL
540
WISVARYHIE
550
VNRVPAGNWV
560
LIEGVDQPIV
570
KTATITEPRG
580
NEEAQIFRPL
590
KFNTTSVIKI
600
AVEPVNPSEL
610
PKMLDGLRKV
620
NKSYPSLTTK
630
VEESGEHVIL
640
GTGELYLDCV
650
MHDLRKMYSE
660
IDIKVADPVV
670
TFCETVVETS
680
SLKCFAETPN
690
KKNKITMIAE
700
PLEKGLAEDI
710
ENEVVQITWN
720
RKKLGEFFQT
730
KYDWDLLAAR
740
SIWAFGPDAT
750
GPNILVDDTL
760
PSEVDKALLG
770
SVKDSIVQGF
780
QWGTREGPLC
790
DELIRNVKFK
800
ILDAVVAQEP
810
LHRGGGQIIP
820
TARRVVYSAF
830
LMATPRLMEP
840
YYFVEVQAPA
850
DCVSAVYTVL
860
ARRRGHVTQD
870
APIPGSPLYT
880
IKAFIPAIDS
890
FGFETDLRTH
900
TQGQAFSLSV
910
FHHWQIVPGD
920
PLDKSIVIRP
930
LEPQPAPHLA
940
REFMIKTRRR
950
KGLSEDVSIS
960
KFFDDPMLLE
970
LAKQDVVLNY
PM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015030 | Cajal body |
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0030623 | U5 snRNA binding |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:0000387 | spliceosomal snRNP assembly |
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
| Biological Process | GO:0000388 | spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.