Overview
| Uniprot ID | Q15036 |
|---|
| Protein Name | Sorting nexin-17 |
|---|
| Gene Name | SNX17 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 435 |
SMVKLSSKLSAVSLR |
Function
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798)
Protein Sequence
10
MHFSIPETES
20
RSGDSGGSAY
30
VAYNIHVNGV
40
LHCRVRYSQL
50
LGLHEQLRKE
60
YGANVLPAFP
70
PKKLFSLTPA
80
EVEQRREQLE
90
KYMQAVRQDP
100
LLGSSETFNS
110
FLRRAQQETQ
120
QVPTEEVSLE
130
VLLSNGQKVL
140
VNVLTSDQTE
150
DVLEAVAAKL
160
DLPDDLIGYF
170
SLFLVREKED
180
GAFSFVRKLQ
190
EFELPYVSVT
200
SLRSQEYKIV
210
LRKSYWDSAY
220
DDDVMENRVG
230
LNLLYAQTVS
240
DIERGWILVT
250
KEQHRQLKSL
260
QEKVSKKEFL
270
RLAQTLRHYG
280
YLRFDACVAD
290
FPEKDCPVVV
300
SAGNSELSLQ
310
LRLPGQQLRE
320
GSFRVTRMRC
330
WRVTSSVPLP
340
SGSTSSPGRG
350
RGEVRLELAF
360
EYLMSKDRLQ
370
WVTITSPQAI
380
MMSICLQSMV
390
DELMVKKSGG
400
SIRKMLRRRV
410
GGTLRRSDSQ
420
QAVKSPPLLE
430
SPDATRESMV
440
KLSSKLSAVS
450
LRGIGSPSTD
460
ASASDVHGNF
470
AFEGIGDEDL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0050750 |
low-density lipoprotein particle receptor binding |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Biological Process |
GO:0006707 |
cholesterol catabolic process |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0016197 |
endosomal transport |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0030100 |
regulation of endocytosis |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.