Search Results
Overview
| Uniprot ID | Q15041 |
|---|---|
| Protein Name | ADP-ribosylation factor-like protein 6-interacting protein 1 |
| Gene Name | ARL6IP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | EICSNLVKTRRRAVG |
| 130 | WKRLFTLKEEKPKMY |
Function
Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0071782 | endoplasmic reticulum tubular network |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005784 | Sec61 translocon complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006613 | cotranslational protein targeting to membrane |
| Biological Process | GO:0071787 | endoplasmic reticulum tubular network formation |
| Biological Process | GO:1990809 | endoplasmic reticulum tubular network membrane organization |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0002038 | positive regulation of L-glutamate import across plasma membrane |
| Biological Process | GO:1903371 | regulation of endoplasmic reticulum tubular network organization |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.