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Overview

Uniprot IDQ15050
Protein NameRibosome biogenesis regulatory protein homolog
Gene NameRRS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
184 AKKERVAKNELNRLR
198 RNLARAHKMQLPSAA
226 GRAMQVAKVSTASVG
253 RGSGKKRKFQPLFGD
266 GDFAAEKKNQLELLR
278 LLRVMNSKKPQLDVT
335 PSQGGKRKGGLGGKM
341 RKGGLGGKMNSGPPG
352 GPPGLGGKRKGGQRP

Function

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus

Protein Sequence

10 MEGQSVEELL 20 AKAEQDEAEK 30 LQRITVHKEL 40 ELQFDLGNLL 50 ASDRNPPTGL 60 RCAGPTPEAE 70 LQALARDNTQ 80 LLINQLWQLP 90 TERVEEAIVA 100 RLPEPTTRLP 110 REKPLPRPRP 120 LTRWQQFARL 130 KGIRPKKKTN 140 LVWDEVSGQW 150 RRRWGYQRAR 160 DDTKEWLIEV 170 PGNADPLEDQ 180 FAKRIQAKKE 190 RVAKNELNRL 200 RNLARAHKMQ 210 LPSAAGLHPT 220 GHQSKEELGR 230 AMQVAKVSTA 240 SVGRFQERLP 250 KEKVPRGSGK 260 KRKFQPLFGD 270 FAAEKKNQLE 280 LLRVMNSKKP 290 QLDVTRATNK 300 QMREEDQEEA 310 AKRRKMSQKG 320 KRKGGRQGPG 330 GKRKGGPPSQ 340 GGKRKGGLGG 350 KMNSGPPGLG 360 GKRKGGQRPG GKRRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0030687 preribosome, large subunit precursor
Molecular Function GO:0008097 5S rRNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0007080 mitotic metaphase chromosome alignment
Biological Process GO:1902570 protein localization to nucleolus
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0000027 ribosomal large subunit assembly
Biological Process GO:0042273 ribosomal large subunit biogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.