Search Results

Overview

Uniprot ID	Q15057
Protein Name	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Gene Name	ACAP2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
543	EKRLSISKFGPGDQV

Function

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672)

Protein Sequence

10 MKMTVDFEEC 20 LKDSPRFRAA 30 LEEVEGDVAE 40 LELKLDKLVK 50 LCIAMIDTGK 60 AFCVANKQFM 70 NGIRDLAQYS 80 SNDAVVETSL 90 TKFSDSLQEM 100 INFHTILFDQ 110 TQRSIKAQLQ 120 NFVKEDLRKF 130 KDAKKQFEKV 140 SEEKENALVK 150 NAQVQRNKQH 160 EVEEATNILT 170 ATRKCFRHIA 180 LDYVLQINVL 190 QSKRRSEILK 200 SMLSFMYAHL 210 AFFHQGYDLF 220 SELGPYMKDL 230 GAQLDRLVVD 240 AAKEKREMEQ 250 KHSTIQQKDF 260 SSDDSKLEYN 270 VDAANGIVME 280 GYLFKRASNA 290 FKTWNRRWFS 300 IQNNQLVYQK 310 KFKDNPTVVV 320 EDLRLCTVKH 330 CEDIERRFCF 340 EVVSPTKSCM 350 LQADSEKLRQ 360 AWIKAVQTSI 370 ATAYREKGDE 380 SEKLDKKSSP 390 STGSLDSGNE 400 SKEKLLKGES 410 ALQRVQCIPG 420 NASCCDCGLA 430 DPRWASINLG 440 ITLCIECSGI 450 HRSLGVHFSK 460 VRSLTLDTWE 470 PELLKLMCEL 480 GNDVINRVYE 490 ANVEKMGIKK 500 PQPGQRQEKE 510 AYIRAKYVER 520 KFVDKYSISL 530 SPPEQQKKFV 540 SKSSEEKRLS 550 ISKFGPGDQV 560 RASAQSSVRS 570 NDSGIQQSSD 580 DGRESLPSTV 590 SANSLYEPEG 600 ERQDSSMFLD 610 SKHLNPGLQL 620 YRASYEKNLP 630 KMAEALAHGA 640 DVNWANSEEN 650 KATPLIQAVL 660 GGSLVTCEFL 670 LQNGANVNQR 680 DVQGRGPLHH 690 ATVLGHTGQV 700 CLFLKRGANQ 710 HATDEEGKDP 720 LSIAVEAANA 730 DIVTLLRLAR 740 MNEEMRESEG 750 LYGQPGDETY 760 QDIFRDFSQM 770 ASNNPEKLNR FQQDSQKF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0001726	ruffle
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0030029	actin filament-based process
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus
Biological Process	GO:0032456	endocytic recycling

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.