Search Results

Overview

Uniprot IDQ15058
Protein NameKinesin-like protein KIF14
Gene NameKIF14
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
269 EIAKTSNKFGSLEKR
305 SPAPSILKNRMSNLQ
325 KSSFLANKQERSAEN
778 EKFEQAEKRKLQETK

Function

Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302)

Protein Sequence

10 MSLHSTHNRN 20 NSGDILDIPS 30 SQNSSSLNAL 40 THSSRLKLHL 50 KSDMSECEND 60 DPLLRSAGKV 70 RDINRTYVIS 80 ASRKTADMPL 90 TPNPVGRLAL 100 QRRTTRNKES 110 SLLVSELEDT 120 TEKTAETRLT 130 LQRRAKTDSA 140 EKWKTAEIDS 150 VKMTLNVGGE 160 TENNGVSKES 170 RTNVRIVNNA 180 KNSFVASSVP 190 LDEDPQVIEM 200 MADKKYKETF 210 SAPSRANENV 220 ALKYSSNRPP 230 IASLSQTEVV 240 RSGHLTTKPT 250 QSKLDIKVLG 260 TGNLYHRSIG 270 KEIAKTSNKF 280 GSLEKRTPTK 290 CTTEHKLTTK 300 CSLPQLKSPA 310 PSILKNRMSN 320 LQVKQRPKSS 330 FLANKQERSA 340 ENTILPEEET 350 VVQNTSAGKD 360 PLKVENSQVT 370 VAVRVRPFTK 380 REKIEKASQV 390 VFMSGKEITV 400 EHPDTKQVYN 410 FIYDVSFWSF 420 DECHPHYASQ 430 TTVYEKLAAP 440 LLERAFEGFN 450 TCLFAYGQTG 460 SGKSYTMMGF 470 SEEPGIIPRF 480 CEDLFSQVAR 490 KQTQEVSYHI 500 EMSFFEVYNE 510 KIHDLLVCKD 520 ENGQRKQPLR 530 VREHPVYGPY 540 VEALSMNIVS 550 SYADIQSWLE 560 LGNKQRATAA 570 TGMNDKSSRS 580 HSVFTLVMTQ 590 TKTEFVEGEE 600 HDHRITSRIN 610 LIDLAGSERC 620 STAHTNGDRL 630 KEGVSINKSL 640 LTLGKVISAL 650 SEQANQRSVF 660 IPYRESVLTW 670 LLKESLGGNS 680 KTAMIATISP 690 AASNIEETLS 700 TLRYANQARL 710 IVNIAKVNED 720 MNAKLIRELK 730 AEIAKLKAAQ 740 RNSRNIDPER 750 YRLCRQEITS 760 LRMKLHQQER 770 DMAEMQRVWK 780 EKFEQAEKRK 790 LQETKELQKA 800 GIMFQMDNHL 810 PNLVNLNEDP 820 QLSEMLLYMI 830 KEGTTTVGKY 840 KPNSSHDIQL 850 SGVLIADDHC 860 TIKNFGGTVS 870 IIPVGEAKTY 880 VNGKHILEIT 890 VLRHGDRVIL 900 GGDHYFRFNH 910 PVEVQKGKRP 920 SGRDTPISEG 930 PKDFEFAKNE 940 LLMAQRSQLE 950 AEIKEAQLKA 960 KEEMMQGIQI 970 AKEMAQQELS 980 SQKAAYESKI 990 KALEAELREE 1000 SQRKKMQEIN 1010 NQKANHKIEE 1020 LEKAKQHLEQ 1030 EIYVNKKRLE 1040 METLATKQAL 1050 EDHSIRHARI 1060 LEALETEKQK 1070 IAKEVQILQQ 1080 NRNNRDKTFT 1090 VQTTWSSMKL 1100 SMMIQEANAI 1110 SSKLKTYYVF 1120 GRHDISDKSS 1130 SDTSIRVRNL 1140 KLGISTFWSL 1150 EKFESKLAAM 1160 KELYESNGSN 1170 RGEDAFCDPE 1180 DEWEPDITDA 1190 PVSSLSRRRS 1200 RSLMKNRRIS 1210 GCLHDIQVHP 1220 IKNLHSSHSS 1230 GLMDKSSTIY 1240 SNSAESFLPG 1250 ICKELIGSSL 1260 DFFGQSYDEE 1270 RTIADSLINS 1280 FLKIYNGLFA 1290 ISKAHEEQDE 1300 ESQDNLFSSD 1310 RAIQSLTIQT 1320 ACAFEQLVVL 1330 MKHWLSDLLP 1340 CTNIARLEDE 1350 LRQEVKKLGG 1360 YLQLFLQGCC 1370 LDISSMIKEA 1380 QKNAIQIVQQ 1390 AVKYVGQLAV 1400 LKGSKLHFLE 1410 NGNNKAASVQ 1420 EEFMDAVCDG 1430 VGLGMKILLD 1440 SGLEKAKELQ 1450 HELFRQCTKN 1460 EVTKEMKTNA 1470 MGLIRSLENI 1480 FAESKIKSFR 1490 RQVQEENFEY 1500 QDFKRMVNRA 1510 PEFLKLKHCL 1520 EKAIEIIISA 1530 LKGCHSDINL 1540 LQTCVESIRN 1550 LASDFYSDFS 1560 VPSTSVGSYE 1570 SRVTHIVHQE 1580 LESLAKSLLF 1590 CFESEESPDL 1600 LKPWETYNQN 1610 TKEEHQQSKS 1620 SGIDGSKNKG 1630 VPKRVYELHG 1640 SSPAVSSEEC TPSRIQWV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005871 kinesin complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0030496 midbody
Cellular Component GO:0005634 nucleus
Cellular Component GO:0051233 spindle midzone
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Molecular Function GO:0030165 PDZ domain binding
Molecular Function GO:0008574 plus-end-directed microtubule motor activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0015631 tubulin binding
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0051301 cell division
Biological Process GO:0021846 cell proliferation in forebrain
Biological Process GO:0021695 cerebellar cortex development
Biological Process GO:0021685 cerebellar granular layer structural organization
Biological Process GO:0021693 cerebellar Purkinje cell layer structural organization
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0021766 hippocampus development
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0007080 mitotic metaphase chromosome alignment
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0033624 negative regulation of integrin activation
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0021772 olfactory bulb development
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0001558 regulation of cell growth
Biological Process GO:1903429 regulation of cell maturation
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:2000045 regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0010389 regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0031641 regulation of myelination
Biological Process GO:0043523 regulation of neuron apoptotic process
Biological Process GO:0032487 regulation of Rap protein signal transduction
Biological Process GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0034446 substrate adhesion-dependent cell spreading

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.