Search Results

Overview

Uniprot IDQ15063
Protein NamePeriostin
Gene NamePOSTN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
172 LHSHMINKRMLTKDL
302 VASEALMKYHILNTL
475 IENSCMEKGSKQGRN
497 EIIKPAEKSLHEKLK
549 KGMTSEEKEILIRDK
55 QILGTKKKYFSTCKN
61 KKYFSTCKNWYKKSI
610 LVNELKSKESDIMTT
704 GPTLTKVKIEGEPEF
72 KKSICGQKTTVLYEC
777 GETEETLKKLLQEEV

Function

Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity)

Protein Sequence

10 MIPFLPMFSL 20 LLLLIVNPIN 30 ANNHYDKILA 40 HSRIRGRDQG 50 PNVCALQQIL 60 GTKKKYFSTC 70 KNWYKKSICG 80 QKTTVLYECC 90 PGYMRMEGMK 100 GCPAVLPIDH 110 VYGTLGIVGA 120 TTTQRYSDAS 130 KLREEIEGKG 140 SFTYFAPSNE 150 AWDNLDSDIR 160 RGLESNVNVE 170 LLNALHSHMI 180 NKRMLTKDLK 190 NGMIIPSMYN 200 NLGLFINHYP 210 NGVVTVNCAR 220 IIHGNQIATN 230 GVVHVIDRVL 240 TQIGTSIQDF 250 IEAEDDLSSF 260 RAAAITSDIL 270 EALGRDGHFT 280 LFAPTNEAFE 290 KLPRGVLERI 300 MGDKVASEAL 310 MKYHILNTLQ 320 CSESIMGGAV 330 FETLEGNTIE 340 IGCDGDSITV 350 NGIKMVNKKD 360 IVTNNGVIHL 370 IDQVLIPDSA 380 KQVIELAGKQ 390 QTTFTDLVAQ 400 LGLASALRPD 410 GEYTLLAPVN 420 NAFSDDTLSM 430 DQRLLKLILQ 440 NHILKVKVGL 450 NELYNGQILE 460 TIGGKQLRVF 470 VYRTAVCIEN 480 SCMEKGSKQG 490 RNGAIHIFRE 500 IIKPAEKSLH 510 EKLKQDKRFS 520 TFLSLLEAAD 530 LKELLTQPGD 540 WTLFVPTNDA 550 FKGMTSEEKE 560 ILIRDKNALQ 570 NIILYHLTPG 580 VFIGKGFEPG 590 VTNILKTTQG 600 SKIFLKEVND 610 TLLVNELKSK 620 ESDIMTTNGV 630 IHVVDKLLYP 640 ADTPVGNDQL 650 LEILNKLIKY 660 IQIKFVRGST 670 FKEIPVTVYT 680 TKIITKVVEP 690 KIKVIEGSLQ 700 PIIKTEGPTL 710 TKVKIEGEPE 720 FRLIKEGETI 730 TEVIHGEPII 740 KKYTKIIDGV 750 PVEITEKETR 760 EERIITGPEI 770 KYTRISTGGG 780 ETEETLKKLL 790 QEEVTKVTKF 800 IEGGDGHLFE 810 DEEIKRLLQG 820 DTPVRKLQAN 830 KKVQGSRRRL REGRSQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0050839 cell adhesion molecule binding
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0071307 cellular response to vitamin K
Biological Process GO:0030198 extracellular matrix organization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.