Search Results

Overview

Uniprot IDQ15067
Protein NamePeroxisomal acyl-coenzyme A oxidase 1
Gene NameACOX1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
216 IREIGTHKPLPGITV
260 LMKYAQVKPDGTYVK
267 KPDGTYVKPLSNKLT
437 QTARFLMKSYDQVHS
500 RLVEIAAKNLQKEVI
504 IAAKNLQKEVIHRKS
549 KLLKIQDKAIQAVLR
643 AKNSPLNKAEVHESY
651 AEVHESYKHLKSLQS
654 HESYKHLKSLQSKL*

Function

Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (VLCFAs) (PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382, PubMed:7876265). Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) (PubMed:17458872, PubMed:17603022, PubMed:7876265). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes (Probable). Involved in VLCFA-dependent hepatic-to-adipose tissue inter-organ signaling in response to diet. Through hepatic beta-oxidation of THA, may regulate THA systemic levels and THA-dependent activation of FFAR4 signaling in adipocytes, limiting adipose tissue thermogenesis (By similarity)

Protein Sequence

10 MNPDLRRERD 20 SASFNPELLT 30 HILDGSPEKT 40 RRRREIENMI 50 LNDPDFQHED 60 LNFLTRSQRY 70 EVAVRKSAIM 80 VKKMREFGIA 90 DPDEIMWFKK 100 LHLVNFVEPV 110 GLNYSMFIPT 120 LLNQGTTAQK 130 EKWLLSSKGL 140 QIIGTYAQTE 150 MGHGTHLRGL 160 ETTATYDPET 170 QEFILNSPTV 180 TSIKWWPGGL 190 GKTSNHAIVL 200 AQLITKGKCY 210 GLHAFIVPIR 220 EIGTHKPLPG 230 ITVGDIGPKF 240 GYDEIDNGYL 250 KMDNHRIPRE 260 NMLMKYAQVK 270 PDGTYVKPLS 280 NKLTYGTMVF 290 VRSFLVGEAA 300 RALSKACTIA 310 IRYSAVRHQS 320 EIKPGEPEPQ 330 ILDFQTQQYK 340 LFPLLATAYA 350 FQFVGAYMKE 360 TYHRINEGIG 370 QGDLSELPEL 380 HALTAGLKAF 390 TSWTANTGIE 400 ACRMACGGHG 410 YSHCSGLPNI 420 YVNFTPSCTF 430 EGENTVMMLQ 440 TARFLMKSYD 450 QVHSGKLVCG 460 MVSYLNDLPS 470 QRIQPQQVAV 480 WPTMVDINSP 490 ESLTEAYKLR 500 AARLVEIAAK 510 NLQKEVIHRK 520 SKEVAWNLTS 530 VDLVRASEAH 540 CHYVVVKLFS 550 EKLLKIQDKA 560 IQAVLRSLCL 570 LYSLYGISQN 580 AGDFLQGSIM 590 TEPQITQVNQ 600 RVKELLTLIR 610 SDAVALVDAF 620 DFQDVTLGSV 630 LGRYDGNVYE 640 NLFEWAKNSP 650 LNKAEVHESY 660 KHLKSLQSKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005782 peroxisomal matrix
Cellular Component GO:0005778 peroxisomal membrane
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0003997 acyl-CoA oxidase activity
Molecular Function GO:0071949 FAD binding
Molecular Function GO:0005504 fatty acid binding
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0120524 long-chain fatty acyl-CoA oxidase activity
Molecular Function GO:0030165 PDZ domain binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0009062 fatty acid catabolic process
Biological Process GO:0019395 fatty acid oxidation
Biological Process GO:0006091 generation of precursor metabolites and energy
Biological Process GO:0050665 hydrogen peroxide biosynthetic process
Biological Process GO:0055088 lipid homeostasis
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0016559 peroxisome fission
Biological Process GO:0006693 prostaglandin metabolic process
Biological Process GO:0140493 very long-chain fatty acid beta-oxidation
Biological Process GO:0000038 very long-chain fatty acid metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.