Search Results

Overview

Uniprot IDQ15075
Protein NameEarly endosome antigen 1
Gene NameEEA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1165 ITNLKDAKQLLIQQK
1348 HTQALNRKWAEDNEV
1396 NALTPSSKKPVRVCD
333 NEESVSKKNIQATLH
387 ELSEVETKYQHLKAE
485 ELQHQLDKTKQQHQE
503 LQQSTTAKLREAQND
536 EALLQKSKENISLLE

Function

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking

Protein Sequence

10 MLRRILQRTP 20 GRVGSQGSDL 30 DSSATPINTV 40 DVNNESSSEG 50 FICPQCMKSL 60 GSADELFKHY 70 EAVHDAGNDS 80 GHGGESNLAL 90 KRDDVTLLRQ 100 EVQDLQASLK 110 EEKWYSEELK 120 KELEKYQGLQ 130 QQEAKPDGLV 140 TDSSAELQSL 150 EQQLEEAQTE 160 NFNIKQMKDL 170 FEQKAAQLAT 180 EIADIKSKYD 190 EERSLREAAE 200 QKVTRLTEEL 210 NKEATVIQDL 220 KTELLQRPGI 230 EDVAVLKKEL 240 VQVQTLMDNM 250 TLERERESEK 260 LKDECKKLQS 270 QYASSEATIS 280 QLRSELAKGP 290 QEVAVYVQEL 300 QKLKSSVNEL 310 TQKNQTLTEN 320 LLKKEQDYTK 330 LEEKHNEESV 340 SKKNIQATLH 350 QKDLDCQQLQ 360 SRLSASETSL 370 HRIHVELSEK 380 GEATQKLKEE 390 LSEVETKYQH 400 LKAEFKQLQQ 410 QREEKEQHGL 420 QLQSEINQLH 430 SKLLETERQL 440 GEAHGRLKEQ 450 RQLSSEKLMD 460 KEQQVADLQL 470 KLSRLEEQLK 480 EKVTNSTELQ 490 HQLDKTKQQH 500 QEQQALQQST 510 TAKLREAQND 520 LEQVLRQIGD 530 KDQKIQNLEA 540 LLQKSKENIS 550 LLEKEREDLY 560 AKIQAGEGET 570 AVLNQLQEKN 580 HTLQEQVTQL 590 TEKLKNQSES 600 HKQAQENLHD 610 QVQEQKAHLR 620 AAQDRVLSLE 630 TSVNELNSQL 640 NESKEKVSQL 650 DIQIKAKTEL 660 LLSAEAAKTA 670 QRADLQNHLD 680 TAQNALQDKQ 690 QELNKITTQL 700 DQVTAKLQDK 710 QEHCSQLESH 720 LKEYKEKYLS 730 LEQKTEELEG 740 QIKKLEADSL 750 EVKASKEQAL 760 QDLQQQRQLN 770 TDLELRATEL 780 SKQLEMEKEI 790 VSSTRLDLQK 800 KSEALESIKQ 810 KLTKQEEEKK 820 ILKQDFETLS 830 QETKIQHEEL 840 NNRIQTTVTE 850 LQKVKMEKEA 860 LMTELSTVKD 870 KLSKVSDSLK 880 NSKSEFEKEN 890 QKGKAAILDL 900 EKTCKELKHQ 910 LQVQMENTLK 920 EQKELKKSLE 930 KEKEASHQLK 940 LELNSMQEQL 950 IQAQNTLKQN 960 EKEEQQLQGN 970 INELKQSSEQ 980 KKKQIEALQG 990 ELKIAVLQKT 1000 ELENKLQQQL 1010 TQAAQELAAE 1020 KEKISVLQNN 1030 YEKSQETFKQ 1040 LQSDFYGRES 1050 ELLATRQDLK 1060 SVEEKLSLAQ 1070 EDLISNRNQI 1080 GNQNKLIQEL 1090 KTAKATLEQD 1100 SAKKEQQLQE 1110 RCKALQDIQK 1120 EKSLKEKELV 1130 NEKSKLAEIE 1140 EIKCRQEKEI 1150 TKLNEELKSH 1160 KLESIKEITN 1170 LKDAKQLLIQ 1180 QKLELQGKAD 1190 SLKAAVEQEK 1200 RNQQILKDQV 1210 KKEEEELKKE 1220 FIEKEAKLHS 1230 EIKEKEVGMK 1240 KHEENEAKLT 1250 MQITALNENL 1260 GTVKKEWQSS 1270 QRRVSELEKQ 1280 TDDLRGEIAV 1290 LEATVQNNQD 1300 ERRALLERCL 1310 KGEGEIEKLQ 1320 TKVLELQRKL 1330 DNTTAAVQEL 1340 GRENQSLQIK 1350 HTQALNRKWA 1360 EDNEVQNCMA 1370 CGKGFSVTVR 1380 RHHCRQCGNI 1390 FCAECSAKNA 1400 LTPSSKKPVR 1410 VCDACFNDLQ G

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044308 axonal spine
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098842 postsynaptic early endosome
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Molecular Function GO:0005545 1-phosphatidylinositol binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0030742 GTP-dependent protein binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0099565 chemical synaptic transmission, postsynaptic
Biological Process GO:0045022 early endosome to late endosome transport
Biological Process GO:0006897 endocytosis
Biological Process GO:0044788 host-mediated perturbation of viral process
Biological Process GO:0016189 synaptic vesicle to endosome fusion
Biological Process GO:0006906 vesicle fusion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.