Search Results
Overview
| Uniprot ID | Q15078 |
|---|---|
| Protein Name | Cyclin-dependent kinase 5 activator 1 |
| Gene Name | CDK5R1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 62 | IVAVSAKKKNSKKVQ |
Function
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution
Protein Sequence
10
MGTVLSLSPS
20
YRKATLFEDG
30
AATVGHYTAV
40
QNSKNAKDKN
50
LKRHSIISVL
60
PWKRIVAVSA
70
KKKNSKKVQP
80
NSSYQNNITH
90
LNNENLKKSL
100
SCANLSTFAQ
110
PPPAQPPAPP
120
ASQLSGSQTG
130
GSSSVKKAPH
140
PAVTSAGTPK
150
RVIVQASTSE
160
LLRCLGEFLC
170
RRCYRLKHLS
180
PTDPVLWLRS
190
VDRSLLLQGW
200
QDQGFITPAN
210
VVFLYMLCRD
220
VISSEVGSDH
230
ELQAVLLTCL
240
YLSYSYMGNE
250
ISYPLKPFLV
260
ESCKEAFWDR
270
CLSVINLMSS
280
KMLQINADPH
290
YFTQVFSDLK
300
NESGQEDKKR
LLLGLDR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0016533 | protein kinase 5 complex |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity |
| Molecular Function | GO:0035255 | ionotropic glutamate receptor binding |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0030295 | protein kinase activator activity |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0007413 | axonal fasciculation |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0021799 | cerebral cortex radially oriented cell migration |
| Biological Process | GO:0048013 | ephrin receptor signaling pathway |
| Biological Process | GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway |
| Biological Process | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0007158 | neuron cell-cell adhesion |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:0018107 | peptidyl-threonine phosphorylation |
| Biological Process | GO:0031116 | positive regulation of microtubule polymerization |
| Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| Biological Process | GO:0061001 | regulation of dendritic spine morphogenesis |
| Biological Process | GO:0016241 | regulation of macroautophagy |
| Biological Process | GO:0045664 | regulation of neuron differentiation |
| Biological Process | GO:0048511 | rhythmic process |
| Cellular Component | GO:0043292 | contractile muscle fiber |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.