Search Results

Overview

Uniprot IDQ15084
Protein NameProtein disulfide-isomerase A6
Gene NamePDIA6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 IKIFGSNKNRPEDYQ
150 SGGYSSGKQGRSDSS
160 RSDSSSKKDVIELTD
208 AAAASEVKEQTKGKV
216 EQTKGKVKLAAVDAT
245 PTIKIFQKGESPVDY
73 KKAATALKDVVKVGA
77 TALKDVVKVGAVDAD

Function

May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936)

Protein Sequence

10 MALLVLGLVS 20 CTFFLAVNGL 30 YSSSDDVIEL 40 TPSNFNREVI 50 QSDSLWLVEF 60 YAPWCGHCQR 70 LTPEWKKAAT 80 ALKDVVKVGA 90 VDADKHHSLG 100 GQYGVQGFPT 110 IKIFGSNKNR 120 PEDYQGGRTG 130 EAIVDAALSA 140 LRQLVKDRLG 150 GRSGGYSSGK 160 QGRSDSSSKK 170 DVIELTDDSF 180 DKNVLDSEDV 190 WMVEFYAPWC 200 GHCKNLEPEW 210 AAAASEVKEQ 220 TKGKVKLAAV 230 DATVNQVLAS 240 RYGIRGFPTI 250 KIFQKGESPV 260 DYDGGRTRSD 270 IVSRALDLFS 280 DNAPPPELLE 290 IINEDIAKRT 300 CEEHQLCVVA 310 VLPHILDTGA 320 AGRNSYLEVL 330 LKLADKYKKK 340 MWGWLWTEAG 350 AQSELETALG 360 IGGFGYPAMA 370 AINARKMKFA 380 LLKGSFSEQG 390 INEFLRELSF 400 GRGSTAPVGG 410 GAFPTIVERE 420 PWDGRDGELP 430 VEDDIDLSDV 440 ELDDLGKDEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0034663 endoplasmic reticulum chaperone complex
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0042470 melanosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0003756 protein disulfide isomerase activity
Molecular Function GO:0015035 protein-disulfide reductase activity
Biological Process GO:0006457 protein folding
Biological Process GO:0034976 response to endoplasmic reticulum stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.