Search Results
Overview
| Uniprot ID | Q15120 |
|---|---|
| Protein Name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial |
| Gene Name | PDK3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 278 | KTLVTLGKEDLSIKI |
Function
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species
Protein Sequence
10
MRLFRWLLKQ
20
PVPKQIERYS
30
RFSPSPLSIK
40
QFLDFGRDNA
50
CEKTSYMFLR
60
KELPVRLANT
70
MREVNLLPDN
80
LLNRPSVGLV
90
QSWYMQSFLE
100
LLEYENKSPE
110
DPQVLDNFLQ
120
VLIKVRNRHN
130
DVVPTMAQGV
140
IEYKEKFGFD
150
PFISTNIQYF
160
LDRFYTNRIS
170
FRMLINQHTL
180
LFGGDTNPVH
190
PKHIGSIDPT
200
CNVADVVKDA
210
YETAKMLCEQ
220
YYLVAPELEV
230
EEFNAKAPDK
240
PIQVVYVPSH
250
LFHMLFELFK
260
NSMRATVELY
270
EDRKEGYPAV
280
KTLVTLGKED
290
LSIKISDLGG
300
GVPLRKIDRL
310
FNYMYSTAPR
320
PSLEPTRAAP
330
LAGFGYGLPI
340
SRLYARYFQG
350
DLKLYSMEGV
360
GTDAVIYLKA
370
LSSESFERLP
380
VFNKSAWRHY
390
KTTPEADDWS
400
NPSSEPRDAS
KYKAKQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| Biological Process | GO:0071398 | cellular response to fatty acid |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0097411 | hypoxia-inducible factor-1alpha signaling pathway |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:0035357 | peroxisome proliferator activated receptor signaling pathway |
| Biological Process | GO:0010906 | regulation of glucose metabolic process |
| Biological Process | GO:0010510 | regulation of pyruvate decarboxylation to acetyl-CoA |
| Biological Process | GO:2000377 | regulation of reactive oxygen species metabolic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.