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Overview

Uniprot ID	Q15121
Protein Name	Astrocytic phosphoprotein PEA-15
Gene Name	PEA15
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
128	IKLAPPPKKA*****
129	KLAPPPKKA******
24	LEDLEQLKSACKEDI
98	EEDELDTKLTRIPSA

Function

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface

Protein Sequence

10 MAEYGTLLQD 20 LTNNITLEDL 30 EQLKSACKED 40 IPSEKSEEIT 50 TGSAWFSFLE 60 SHNKLDKDNL 70 SYIEHIFEIS 80 RRPDLLTMVV 90 DYRTRVLKIS 100 EEDELDTKLT 110 RIPSAKKYKD 120 IIRQPSEEEI 130 IKLAPPPKKA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005875	microtubule associated complex
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0000165	MAPK cascade
Biological Process	GO:0046325	negative regulation of D-glucose import across plasma membrane
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.