Search Results

Overview

Uniprot IDQ15125
Protein Name3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Gene NameEBP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 QLWKEYAKGDSRYIL
221 AQSTLDAKATKAKSK

Function

Isomerase that catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers a catalytic step in the postlanosterol biosynthesis of cholesterol

Protein Sequence

10 MTTNAGPLHP 20 YWPQHLRLDN 30 FVPNDRPTWH 40 ILAGLFSVTG 50 VLVVTTWLLS 60 GRAAVVPLGT 70 WRRLSLCWFA 80 VCGFIHLVIE 90 GWFVLYYEDL 100 LGDQAFLSQL 110 WKEYAKGDSR 120 YILGDNFTVC 130 METITACLWG 140 PLSLWVVIAF 150 LRQHPLRFIL 160 QLVVSVGQIY 170 GDVLYFLTEH 180 RDGFQHGELG 190 HPLYFWFYFV 200 FMNALWLVLP 210 GVLVLDAVKH 220 LTHAQSTLDA 230 KATKAKSKKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0031965 nuclear membrane
Molecular Function GO:0000247 C-8 sterol isomerase activity
Molecular Function GO:0047750 cholestenol delta-isomerase activity
Molecular Function GO:0033963 cholesterol-5,6-oxide hydrolase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004769 steroid Delta-isomerase activity
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0033489 cholesterol biosynthetic process via desmosterol
Biological Process GO:0033490 cholesterol biosynthetic process via lathosterol
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0043931 ossification involved in bone maturation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.