Search Results

Overview

Uniprot IDQ15126
Protein NamePhosphomevalonate kinase
Gene NamePMVK
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
48 LRLSGPLKEQYAQEH
69 LLDTSTYKEAFRKDM

Function

Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites

Protein Sequence

10 MAPLGGAPRL 20 VLLFSGKRKS 30 GKDFVTEALQ 40 SRLGADVCAV 50 LRLSGPLKEQ 60 YAQEHGLNFQ 70 RLLDTSTYKE 80 AFRKDMIRWG 90 EEKRQADPGF 100 FCRKIVEGIS 110 QPIWLVSDTR 120 RVSDIQWFRE 130 AYGAVTQTVR 140 VVALEQSRQQ 150 RGWVFTPGVD 160 DAESECGLDN 170 FGDFDWVIEN 180 HGVEQRLEEQ 190 LENLIEFIRS RL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004631 phosphomevalonate kinase activity
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0033489 cholesterol biosynthetic process via desmosterol
Biological Process GO:0033490 cholesterol biosynthetic process via lathosterol
Biological Process GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway
Biological Process GO:0033386 geranylgeranyl diphosphate biosynthetic process
Biological Process GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Biological Process GO:0070723 response to cholesterol
Biological Process GO:0016126 sterol biosynthetic process
Biological Process GO:0036197 zymosterol biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.