Search Results
Overview
| Uniprot ID | Q15131 |
|---|---|
| Protein Name | Cyclin-dependent kinase 10 |
| Gene Name | CDK10 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 356 | ATSEGQSKRCKP*** |
Function
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747)
Protein Sequence
10
MAEPDLECEQ
20
IRLKCIRKEG
30
FFTVPPEHRL
40
GRCRSVKEFE
50
KLNRIGEGTY
60
GIVYRARDTQ
70
TDEIVALKKV
80
RMDKEKDGIP
90
ISSLREITLL
100
LRLRHPNIVE
110
LKEVVVGNHL
120
ESIFLVMGYC
130
EQDLASLLEN
140
MPTPFSEAQV
150
KCIVLQVLRG
160
LQYLHRNFII
170
HRDLKVSNLL
180
MTDKGCVKTA
190
DFGLARAYGV
200
PVKPMTPKVV
210
TLWYRAPELL
220
LGTTTQTTSI
230
DMWAVGCILA
240
ELLAHRPLLP
250
GTSEIHQIDL
260
IVQLLGTPSE
270
NIWPGFSKLP
280
LVGQYSLRKQ
290
PYNNLKHKFP
300
WLSEAGLRLL
310
HFLFMYDPKK
320
RATAGDCLES
330
SYFKEKPLPC
340
EPELMPTFPH
350
HRNKRAAPAT
360
SEGQSKRCKP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:1902018 | negative regulation of cilium assembly |
| Biological Process | GO:0018107 | peptidyl-threonine phosphorylation |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:1902749 | regulation of cell cycle G2/M phase transition |
| Biological Process | GO:0007089 | traversing start control point of mitotic cell cycle |
Reference
PMID: N/A