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Overview

Uniprot IDQ15147
Protein Name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Gene NamePLCB4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
177 TRTFASGKTEKVIFQ
180 FASGKTEKVIFQALK

Function

Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G protein-coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (PubMed:35284927)

Protein Sequence

10 MAKPYEFNWQ 20 KEVPSFLQEG 30 AVFDRYEEES 40 FVFEPNCLFK 50 VDEFGFFLTW 60 RSEGKEGQVL 70 ECSLINSIRS 80 GAIPKDPKIL 90 AALEAVGKSE 100 NDLEGRIVCV 110 CSGTDLVNIS 120 FTYMVAENPE 130 VTKQWVEGLR 140 SIIHNFRANN 150 VSPMTCLKKH 160 WMKLAFMTNT 170 NGKIPVRSIT 180 RTFASGKTEK 190 VIFQALKELG 200 LPSGKNDEIE 210 PTAFSYEKFY 220 ELTQKICPRT 230 DIEDLFKKIN 240 GDKTDYLTVD 250 QLVSFLNEHQ 260 RDPRLNEILF 270 PFYDAKRAMQ 280 IIEMYEPDED 290 LKKKGLISSD 300 GFCRYLMSDE 310 NAPVFLDRLE 320 LYQEMDHPLA 330 HYFISSSHNT 340 YLTGRQFGGK 350 SSVEMYRQVL 360 LAGCRCVELD 370 CWDGKGEDQE 380 PIITHGKAMC 390 TDILFKDVIQ 400 AIKETAFVTS 410 EYPVILSFEN 420 HCSKYQQYKM 430 SKYCEDLFGD 440 LLLKQALESH 450 PLEPGRALPS 460 PNDLKRKILI 470 KNKRLKPEVE 480 KKQLEALRSM 490 MEAGESASPA 500 NILEDDNEEE 510 IESADQEEEA 520 HPEFKFGNEL 530 SADDLGHKEA 540 VANSVKKGLV 550 TVEDEQAWMA 560 SYKYVGATTN 570 IHPYLSTMIN 580 YAQPVKFQGF 590 HVAEERNIHY 600 NMSSFNESVG 610 LGYLKTHAIE 620 FVNYNKRQMS 630 RIYPKGGRVD 640 SSNYMPQIFW 650 NAGCQMVSLN 660 YQTPDLAMQL 670 NQGKFEYNGS 680 CGYLLKPDFM 690 RRPDRTFDPF 700 SETPVDGVIA 710 ATCSVQVISG 720 QFLSDKKIGT 730 YVEVDMYGLP 740 TDTIRKEFRT 750 RMVMNNGLNP 760 VYNEESFVFR 770 KVILPDLAVL 780 RIAVYDDNNK 790 LIGQRILPLD 800 GLQAGYRHIS 810 LRNEGNKPLS 820 LPTIFCNIVL 830 KTYVPDGFGD 840 IVDALSDPKK 850 FLSITEKRAD 860 QMRAMGIETS 870 DIADVPSDTS 880 KNDKKGKANT 890 AKANVTPQSS 900 SELRPTTTAA 910 LASGVEAKKG 920 IELIPQVRIE 930 DLKQMKAYLK 940 HLKKQQKELN 950 SLKKKHAKEH 960 STMQKLHCTQ 970 VDKIVAQYDK 980 EKSTHEKILE 990 KAMKKKGGSN 1000 CLEMKKETEI 1010 KIQTLTSDHK 1020 SKVKEIVAQH 1030 TKEWSEMINT 1040 HSAEEQEIRD 1050 LHLSQQCELL 1060 KKLLINAHEQ 1070 QTQQLKLSHD 1080 RESKEMRAHQ 1090 AKISMENSKA 1100 ISQDKSIKNK 1110 AERERRVREL 1120 NSSNTKKFLE 1130 ERKRLAMKQS 1140 KEMDQLKKVQ 1150 LEHLEFLEKQ 1160 NEQAKEMQQM 1170 VKLEAEMDRR PATVV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004629 C-type glycerophospholipase activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0120548 phosphatidylinositol phospholipase C activity
Molecular Function GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0046488 phosphatidylinositol metabolic process
Biological Process GO:0048015 phosphatidylinositol-mediated signaling
Biological Process GO:0160135 phospholipase C-activating endothelin receptor signaling pathway
Biological Process GO:0051209 release of sequestered calcium ion into cytosol

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.