Search Results

Overview

Uniprot IDQ15149
Protein NamePlectin
Gene NamePLEC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1127 QRCISELKDIRLQLE
1150 RLRLPLDKEPARECA
1165 QRIAEQQKAQAEVEG
1175 AEVEGLGKGVARLSA
1224 LSAIYLEKLKTISLV
1410 EECQRFAKQYINAIK
1438 EPVASPAKKPKVQSG
1439 PVASPAKKPKVQSGS
1508 EVEAALEKQRQLAEA
1573 SEAEIQAKARQAEAA
1659 VELASRVKAEAEAAR
1718 AEAELQSKRASFAEK
1725 KRASFAEKTAQLERS
187 VQKKTFTKWVNKHLI
1908 MEVLLASKARAEEES
1975 AERVLAEKLAAIGEA
2037 ERLAQLRKASDSELE
2073 ALKASFEKAAAGKAE
2099 AEDTLRSKEQAELEA
2129 EAEERVQKSLAAEEE
2142 EEAARQRKAALEEVE
2189 KRLQAEEKAHAFAVQ
2255 VEEAERLKQSAEEQA
2274 QAQAAAEKLRKEAEQ
2309 AEMEKHKKFAEQTLR
2318 AEQTLRQKAQVEQEL
2350 DEELQRLKAEATEAA
236 KGRMRFHKLQNVQIA
2452 AEKMLKEKMQAVQEA
2463 VQEATRLKAEAELLQ
2553 QAEEIGEKLHRTELA
2604 EKLQQEAKLLQLKSE
2652 FIEQEKAKLEQLFQD
2706 AEEGVRRKQEELQQL
2841 SIAGLLLKATNEKLS
2846 LLKATNEKLSVYAAL
2915 ERAVTGYKDPYTGQQ
3027 PLTDKAAKGGELVYT
3091 TGRITVEKIIKIIIT
3182 LSIYNALKKDLLPSD
3183 SIYNALKKDLLPSDM
3237 EKLLSAEKAVTGYRD
3285 GGIVDPSKSHRVPLD
338 NAIIHRHKPLLIDMN
3384 EVPVGGFKGRTVTVW
3420 TGKVTVEKVIKILIT
3469 RAQFEQLKDGKTTVK
3568 EQLLSAEKAVTGYRD
3848 LSIYQALKKGLLSAE
3849 SIYQALKKGLLSAEV
3925 SLFQAMKKELIPTEE
3968 YQRGYLNKDTHDQLS
4027 LTFRGLRKQITMEEL
4152 ERAVTGYKDPYSGKL
4173 MKKGLILKDHGIRLL
4205 LPVEVAYKRGLFDEE
4270 RERKTSSKSSVRKRR
4512 MSAAQALKKGWLYYE
4513 SAAQALKKGWLYYEA
477 EADKNRSKGIYQSLE
567 VRLLAAGKVPQRAGE
923 GHLSGLAKRAKAVVQ
926 SGLAKRAKAVVQLKP

Function

Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity

Protein Sequence

10 MVAGMLMPRD 20 QLRAIYEVLF 30 REGVMVAKKD 40 RRPRSLHPHV 50 PGVTNLQVMR 60 AMASLRARGL 70 VRETFAWCHF 80 YWYLTNEGIA 90 HLRQYLHLPP 100 EIVPASLQRV 110 RRPVAMVMPA 120 RRTPHVQAVQ 130 GPLGSPPKRG 140 PLPTEEQRVY 150 RRKELEEVSP 160 ETPVVPATTQ 170 RTLARPGPEP 180 APATDERDRV 190 QKKTFTKWVN 200 KHLIKAQRHI 210 SDLYEDLRDG 220 HNLISLLEVL 230 SGDSLPREKG 240 RMRFHKLQNV 250 QIALDYLRHR 260 QVKLVNIRND 270 DIADGNPKLT 280 LGLIWTIILH 290 FQISDIQVSG 300 QSEDMTAKEK 310 LLLWSQRMVE 320 GYQGLRCDNF 330 TSSWRDGRLF 340 NAIIHRHKPL 350 LIDMNKVYRQ 360 TNLENLDQAF 370 SVAERDLGVT 380 RLLDPEDVDV 390 PQPDEKSIIT 400 YVSSLYDAMP 410 RVPDVQDGVR 420 ANELQLRWQE 430 YRELVLLLLQ 440 WMRHHTAAFE 450 ERRFPSSFEE 460 IEILWSQFLK 470 FKEMELPAKE 480 ADKNRSKGIY 490 QSLEGAVQAG 500 QLKVPPGYHP 510 LDVEKEWGKL 520 HVAILEREKQ 530 LRSEFERLEC 540 LQRIVTKLQM 550 EAGLCEEQLN 560 QADALLQSDV 570 RLLAAGKVPQ 580 RAGEVERDLD 590 KADSMIRLLF 600 NDVQTLKDGR 610 HPQGEQMYRR 620 VYRLHERLVA 630 IRTEYNLRLK 640 AGVAAPATQV 650 AQVTLQSVQR 660 RPELEDSTLR 670 YLQDLLAWVE 680 ENQHRVDGAE 690 WGVDLPSVEA 700 QLGSHRGLHQ 710 SIEEFRAKIE 720 RARSDEGQLS 730 PATRGAYRDC 740 LGRLDLQYAK 750 LLNSSKARLR 760 SLESLHSFVA 770 AATKELMWLN 780 EKEEEEVGFD 790 WSDRNTNMTA 800 KKESYSALMR 810 ELELKEKKIK 820 ELQNAGDRLL 830 REDHPARPTV 840 ESFQAALQTQ 850 WSWMLQLCCC 860 IEAHLKENAA 870 YFQFFSDVRE 880 AEGQLQKLQE 890 ALRRKYSCDR 900 SATVTRLEDL 910 LQDAQDEKEQ 920 LNEYKGHLSG 930 LAKRAKAVVQ 940 LKPRHPAHPM 950 RGRLPLLAVC 960 DYKQVEVTVH 970 KGDECQLVGP 980 AQPSHWKVLS 990 SSGSEAAVPS 1000 VCFLVPPPNQ 1010 EAQEAVTRLE 1020 AQHQALVTLW 1030 HQLHVDMKSL 1040 LAWQSLRRDV 1050 QLIRSWSLAT 1060 FRTLKPEEQR 1070 QALHSLELHY 1080 QAFLRDSQDA 1090 GGFGPEDRLM 1100 AEREYGSCSH 1110 HYQQLLQSLE 1120 QGAQEESRCQ 1130 RCISELKDIR 1140 LQLEACETRT 1150 VHRLRLPLDK 1160 EPARECAQRI 1170 AEQQKAQAEV 1180 EGLGKGVARL 1190 SAEAEKVLAL 1200 PEPSPAAPTL 1210 RSELELTLGK 1220 LEQVRSLSAI 1230 YLEKLKTISL 1240 VIRGTQGAEE 1250 VLRAHEEQLK 1260 EAQAVPATLP 1270 ELEATKASLK 1280 KLRAQAEAQQ 1290 PTFDALRDEL 1300 RGAQEVGERL 1310 QQRHGERDVE 1320 VERWRERVAQ 1330 LLERWQAVLA 1340 QTDVRQRELE 1350 QLGRQLRYYR 1360 ESADPLGAWL 1370 QDARRRQEQI 1380 QAMPLADSQA 1390 VREQLRQEQA 1400 LLEEIERHGE 1410 KVEECQRFAK 1420 QYINAIKDYE 1430 LQLVTYKAQL 1440 EPVASPAKKP 1450 KVQSGSESVI 1460 QEYVDLRTHY 1470 SELTTLTSQY 1480 IKFISETLRR 1490 MEEEERLAEQ 1500 QRAEERERLA 1510 EVEAALEKQR 1520 QLAEAHAQAK 1530 AQAEREAKEL 1540 QQRMQEEVVR 1550 REEAAVDAQQ 1560 QKRSIQEELQ 1570 QLRQSSEAEI 1580 QAKARQAEAA 1590 ERSRLRIEEE 1600 IRVVRLQLEA 1610 TERQRGGAEG 1620 ELQALRARAE 1630 EAEAQKRQAQ 1640 EEAERLRRQV 1650 QDESQRKRQA 1660 EVELASRVKA 1670 EAEAAREKQR 1680 ALQALEELRL 1690 QAEEAERRLR 1700 QAEVERARQV 1710 QVALETAQRS 1720 AEAELQSKRA 1730 SFAEKTAQLE 1740 RSLQEEHVAV 1750 AQLREEAERR 1760 AQQQAEAERA 1770 REEAERELER 1780 WQLKANEALR 1790 LRLQAEEVAQ 1800 QKSLAQAEAE 1810 KQKEEAEREA 1820 RRRGKAEEQA 1830 VRQRELAEQE 1840 LEKQRQLAEG 1850 TAQQRLAAEQ 1860 ELIRLRAETE 1870 QGEQQRQLLE 1880 EELARLQREA 1890 AAATQKRQEL 1900 EAELAKVRAE 1910 MEVLLASKAR 1920 AEEESRSTSE 1930 KSKQRLEAEA 1940 GRFRELAEEA 1950 ARLRALAEEA 1960 KRQRQLAEED 1970 AARQRAEAER 1980 VLAEKLAAIG 1990 EATRLKTEAE 2000 IALKEKEAEN 2010 ERLRRLAEDE 2020 AFQRRRLEEQ 2030 AAQHKADIEE 2040 RLAQLRKASD 2050 SELERQKGLV 2060 EDTLRQRRQV 2070 EEEILALKAS 2080 FEKAAAGKAE 2090 LELELGRIRS 2100 NAEDTLRSKE 2110 QAELEAARQR 2120 QLAAEEERRR 2130 REAEERVQKS 2140 LAAEEEAARQ 2150 RKAALEEVER 2160 LKAKVEEARR 2170 LRERAEQESA 2180 RQLQLAQEAA 2190 QKRLQAEEKA 2200 HAFAVQQKEQ 2210 ELQQTLQQEQ 2220 SVLDQLRGEA 2230 EAARRAAEEA 2240 EEARVQAERE 2250 AAQSRRQVEE 2260 AERLKQSAEE 2270 QAQARAQAQA 2280 AAEKLRKEAE 2290 QEAARRAQAE 2300 QAALRQKQAA 2310 DAEMEKHKKF 2320 AEQTLRQKAQ 2330 VEQELTTLRL 2340 QLEETDHQKN 2350 LLDEELQRLK 2360 AEATEAARQR 2370 SQVEEELFSV 2380 RVQMEELSKL 2390 KARIEAENRA 2400 LILRDKDNTQ 2410 RFLQEEAEKM 2420 KQVAEEAARL 2430 SVAAQEAARL 2440 RQLAEEDLAQ 2450 QRALAEKMLK 2460 EKMQAVQEAT 2470 RLKAEAELLQ 2480 QQKELAQEQA 2490 RRLQEDKEQM 2500 AQQLAEETQG 2510 FQRTLEAERQ 2520 RQLEMSAEAE 2530 RLKLRVAEMS 2540 RAQARAEEDA 2550 QRFRKQAEEI 2560 GEKLHRTELA 2570 TQEKVTLVQT 2580 LEIQRQQSDH 2590 DAERLREAIA 2600 ELEREKEKLQ 2610 QEAKLLQLKS 2620 EEMQTVQQEQ 2630 LLQETQALQQ 2640 SFLSEKDSLL 2650 QRERFIEQEK 2660 AKLEQLFQDE 2670 VAKAQQLREE 2680 QQRQQQQMEQ 2690 ERQRLVASME 2700 EARRRQHEAE 2710 EGVRRKQEEL 2720 QQLEQQRRQQ 2730 EELLAEENQR 2740 LREQLQLLEE 2750 QHRAALAHSE 2760 EVTASQVAAT 2770 KTLPNGRDAL 2780 DGPAAEAEPE 2790 HSFDGLRRKV 2800 SAQRLQEAGI 2810 LSAEELQRLA 2820 QGHTTVDELA 2830 RREDVRHYLQ 2840 GRSSIAGLLL 2850 KATNEKLSVY 2860 AALQRQLLSP 2870 GTALILLEAQ 2880 AASGFLLDPV 2890 RNRRLTVNEA 2900 VKEGVVGPEL 2910 HHKLLSAERA 2920 VTGYKDPYTG 2930 QQISLFQAMQ 2940 KGLIVREHGI 2950 RLLEAQIATG 2960 GVIDPVHSHR 2970 VPVDVAYRRG 2980 YFDEEMNRVL 2990 ADPSDDTKGF 3000 FDPNTHENLT 3010 YLQLLERCVE 3020 DPETGLCLLP 3030 LTDKAAKGGE 3040 LVYTDSEARD 3050 VFEKATVSAP 3060 FGKFQGKTVT 3070 IWEIINSEYF 3080 TAEQRRDLLR 3090 QFRTGRITVE 3100 KIIKIIITVV 3110 EEQEQKGRLC 3120 FEGLRSLVPA 3130 AELLESRVID 3140 RELYQQLQRG 3150 ERSVRDVAEV 3160 DTVRRALRGA 3170 NVIAGVWLEE 3180 AGQKLSIYNA 3190 LKKDLLPSDM 3200 AVALLEAQAG 3210 TGHIIDPATS 3220 ARLTVDEAVR 3230 AGLVGPEFHE 3240 KLLSAEKAVT 3250 GYRDPYTGQS 3260 VSLFQALKKG 3270 LIPREQGLRL 3280 LDAQLSTGGI 3290 VDPSKSHRVP 3300 LDVACARGCL 3310 DEETSRALSA 3320 PRADAKAYSD 3330 PSTGEPATYG 3340 ELQQRCRPDQ 3350 LTGLSLLPLS 3360 EKAARARQEE 3370 LYSELQARET 3380 FEKTPVEVPV 3390 GGFKGRTVTV 3400 WELISSEYFT 3410 AEQRQELLRQ 3420 FRTGKVTVEK 3430 VIKILITIVE 3440 EVETLRQERL 3450 SFSGLRAPVP 3460 ASELLASGVL 3470 SRAQFEQLKD 3480 GKTTVKDLSE 3490 LGSVRTLLQG 3500 SGCLAGIYLE 3510 DTKEKVSIYE 3520 AMRRGLLRAT 3530 TAALLLEAQA 3540 ATGFLVDPVR 3550 NQRLYVHEAV 3560 KAGVVGPELH 3570 EQLLSAEKAV 3580 TGYRDPYSGS 3590 TISLFQAMQK 3600 GLVLRQHGIR 3610 LLEAQIATGG 3620 IIDPVHSHRV 3630 PVDVAYQRGY 3640 FSEEMNRVLA 3650 DPSDDTKGFF 3660 DPNTHENLTY 3670 RQLLERCVED 3680 PETGLRLLPL 3690 KGAEKAEVVE 3700 TTQVYTEEET 3710 RRAFEETQID 3720 IPGGGSHGGS 3730 TMSLWEVMQS 3740 DLIPEEQRAQ 3750 LMADFQAGRV 3760 TKERMIIIII 3770 EIIEKTEIIR 3780 QQGLASYDYV 3790 RRRLTAEDLF 3800 EARIISLETY 3810 NLLREGTRSL 3820 REALEAESAW 3830 CYLYGTGSVA 3840 GVYLPGSRQT 3850 LSIYQALKKG 3860 LLSAEVARLL 3870 LEAQAATGFL 3880 LDPVKGERLT 3890 VDEAVRKGLV 3900 GPELHDRLLS 3910 AERAVTGYRD 3920 PYTEQTISLF 3930 QAMKKELIPT 3940 EEALRLLDAQ 3950 LATGGIVDPR 3960 LGFHLPLEVA 3970 YQRGYLNKDT 3980 HDQLSEPSEV 3990 RSYVDPSTDE 4000 RLSYTQLLRR 4010 CRRDDGTGQL 4020 LLPLSDARKL 4030 TFRGLRKQIT 4040 MEELVRSQVM 4050 DEATALQLRE 4060 GLTSIEEVTK 4070 NLQKFLEGTS 4080 CIAGVFVDAT 4090 KERLSVYQAM 4100 KKGIIRPGTA 4110 FELLEAQAAT 4120 GYVIDPIKGL 4130 KLTVEEAVRM 4140 GIVGPEFKDK 4150 LLSAERAVTG 4160 YKDPYSGKLI 4170 SLFQAMKKGL 4180 ILKDHGIRLL 4190 EAQIATGGII 4200 DPEESHRLPV 4210 EVAYKRGLFD 4220 EEMNEILTDP 4230 SDDTKGFFDP 4240 NTEENLTYLQ 4250 LMERCITDPQ 4260 TGLCLLPLKE 4270 KKRERKTSSK 4280 SSVRKRRVVI 4290 VDPETGKEMS 4300 VYEAYRKGLI 4310 DHQTYLELSE 4320 QECEWEEITI 4330 SSSDGVVKSM 4340 IIDRRSGRQY 4350 DIDDAIAKNL 4360 IDRSALDQYR 4370 AGTLSITEFA 4380 DMLSGNAGGF 4390 RSRSSSVGSS 4400 SSYPISPAVS 4410 RTQLASWSDP 4420 TEETGPVAGI 4430 LDTETLEKVS 4440 ITEAMHRNLV 4450 DNITGQRLLE 4460 AQACTGGIID 4470 PSTGERFPVT 4480 DAVNKGLVDK 4490 IMVDRINLAQ 4500 KAFCGFEDPR 4510 TKTKMSAAQA 4520 LKKGWLYYEA 4530 GQRFLEVQYL 4540 TGGLIEPDTP 4550 GRVPLDEALQ 4560 RGTVDARTAQ 4570 KLRDVGAYSK 4580 YLTCPKTKLK 4590 ISYKDALDRS 4600 MVEEGTGLRL 4610 LEAAAQSTKG 4620 YYSPYSVSGS 4630 GSTAGSRTGS 4640 RTGSRAGSRR 4650 GSFDATGSGF 4660 SMTFSSSSYS 4670 SSGYGRRYAS 4680 GSSASLGGPE SAVA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005903 brush border
Cellular Component GO:0043034 costamere
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0030056 hemidesmosome
Cellular Component GO:0045111 intermediate filament cytoskeleton
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002102 podosome
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0016528 sarcoplasm
Cellular Component GO:0030018 Z disc
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0030506 ankyrin binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0002162 dystroglycan binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0008307 structural constituent of muscle
Biological Process GO:2000689 actomyosin contractile ring assembly actin filament organization
Biological Process GO:0034332 adherens junction organization
Biological Process GO:0055013 cardiac muscle cell development
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0071498 cellular response to fluid shear stress
Biological Process GO:0071464 cellular response to hydrostatic pressure
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0061436 establishment of skin barrier
Biological Process GO:0010761 fibroblast migration
Biological Process GO:0010467 gene expression
Biological Process GO:0031581 hemidesmosome assembly
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0003334 keratinocyte development
Biological Process GO:0002522 leukocyte migration involved in immune response
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0045445 myoblast differentiation
Biological Process GO:0006997 nucleus organization
Biological Process GO:0032287 peripheral nervous system myelin maintenance
Biological Process GO:0043933 protein-containing complex organization
Biological Process GO:0043114 regulation of vascular permeability
Biological Process GO:0022904 respiratory electron transport chain
Biological Process GO:0032094 response to food
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0048741 skeletal muscle fiber development
Biological Process GO:0014866 skeletal myofibril assembly
Biological Process GO:0010818 T cell chemotaxis
Biological Process GO:0120193 tight junction organization
Biological Process GO:0019226 transmission of nerve impulse
Biological Process GO:0042060 wound healing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.