Search Results

Overview

Uniprot IDQ15155
Protein NameBOS complex subunit NOMO1
Gene NameNOMO1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
630 VNRFCLSKPGVYKVT

Function

Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522)

Protein Sequence

10 MLVGQGAGPL 20 GPAVVTAAVV 30 LLLSGVGPAH 40 GSEDIVVGCG 50 GFVKSDVEIN 60 YSLIEIKLYT 70 KHGTLKYQTD 80 CAPNNGYFMI 90 PLYDKGDFIL 100 KIEPPLGWSF 110 EPTTVELHVD 120 GVSDICTKGG 130 DINFVFTGFS 140 VNGKVLSKGQ 150 PLGPAGVQVS 160 LRNTGTEAKI 170 QSTVTQPGGK 180 FAFFKVLPGD 190 YEILATHPTW 200 ALKEASTTVR 210 VTNSNANAAS 220 PLIVAGYNVS 230 GSVRSDGEPM 240 KGVKFLLFSS 250 LVTKEDVLGC 260 NVSPVPGFQP 270 QDESLVYLCY 280 TVSREDGSFS 290 FYSLPSGGYT 300 VIPFYRGERI 310 TFDVAPSRLD 320 FTVEHDSLKI 330 EPVFHVMGFS 340 VTGRVLNGPE 350 GDGVPEAVVT 360 LNNQIKVKTK 370 ADGSFRLENI 380 TTGTYTIHAQ 390 KEHLYFETVT 400 IKIAPNTPQL 410 ADIIATGFSV 420 CGQISIIRFP 430 DTVKQMNKYK 440 VVLSSQDKDK 450 SLVTVETDAH 460 GSFCFKAKPG 470 TYKVQVMVPE 480 AETRAGLTLK 490 PQTFPLTVTN 500 RPMMDVAFVQ 510 FLASVSGKVS 520 CLDTCGDLLV 530 TLQSLSRQGE 540 KRSLQLSGKV 550 NAMTFTFDNV 560 LPGKYKISIM 570 HEDWCWKNKS 580 LEVEVLEDDM 590 SAVEFRQTGY 600 MLRCSLSHAI 610 TLEFYQDGNG 620 RENVGIYNLS 630 KGVNRFCLSK 640 PGVYKVTPRS 650 CHRFEQAFYT 660 YDTSSPSILT 670 LTAIRHHVLG 680 TITTDKMMDV 690 TVTIKSSIDS 700 EPALVLGPLK 710 SVQELRREQQ 720 LAEIEARRQE 730 REKNGNEEGE 740 ERMTKPPVQE 750 MVDELQGPFS 760 YDFSYWARSG 770 EKITVTPSSK 780 ELLFYPPSME 790 AVVSGESCPG 800 KLIEIHGKAG 810 LFLEGQIHPE 820 LEGVEIVISE 830 KGASSPLITV 840 FTDDKGAYSV 850 GPLHSDLEYT 860 VTSQKEGYVL 870 TAVEGTIGDF 880 KAYALAGVSF 890 EIKAEDDQPL 900 PGVLLSLSGG 910 LFRSNLLTQD 920 NGILTFSNLS 930 PGQYYFKPMM 940 KEFRFEPSSQ 950 MIEVQEGQNL 960 KITITGYRTA 970 YSCYGTVSSL 980 NGEPEQGVAM 990 EAVGQNDCSI 1000 YGEDTVTDEE 1010 GKFRLRGLLP 1020 GCVYHVQLKA 1030 EGNDHIERAL 1040 PHHRVIEVGN 1050 NDIDDVNIIV 1060 FRQINQFDLS 1070 GNVITSSEYL 1080 PTLWVKLYKS 1090 ENLDNPIQTV 1100 SLGQSLFFHF 1110 PPLLRDGENY 1120 VVLLDSTLPR 1130 SQYDYILPQV 1140 SFTAVGYHKH 1150 ITLIFNPTRK 1160 LPEQDIAQGS 1170 YIALPLTLLV 1180 LLAGYNHDKL 1190 IPLLLQLTSR 1200 LQGVRALGQA 1210 ASDNSGPEDA 1220 KRQAKKQKTR RT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0160064 multi-pass translocon complex
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0043022 ribosome binding
Biological Process GO:0160063 multi-pass transmembrane protein insertion into ER membrane

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.