Search Results
Overview
| Uniprot ID | Q15165 |
|---|---|
| Protein Name | Serum paraoxonase/arylesterase 2 |
| Gene Name | PON2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 156 | ENSLLHLKTVKHELL |
| 46 | LPHCHLIKGIEAGSE |
Function
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis
Protein Sequence
10
MGRLVAVGLL
20
GIALALLGER
30
LLALRNRLKA
40
SREVESVDLP
50
HCHLIKGIEA
60
GSEDIDILPN
70
GLAFFSVGLK
80
FPGLHSFAPD
90
KPGGILMMDL
100
KEEKPRAREL
110
RISRGFDLAS
120
FNPHGISTFI
130
DNDDTVYLFV
140
VNHPEFKNTV
150
EIFKFEEAEN
160
SLLHLKTVKH
170
ELLPSVNDIT
180
AVGPAHFYAT
190
NDHYFSDPFL
200
KYLETYLNLH
210
WANVVYYSPN
220
EVKVVAEGFD
230
SANGINISPD
240
DKYIYVADIL
250
AHEIHVLEKH
260
TNMNLTQLKV
270
LELDTLVDNL
280
SIDPSSGDIW
290
VGCHPNGQKL
300
FVYDPNNPPS
310
SEVLRIQNIL
320
SEKPTVTTVY
330
ANNGSVLQGS
340
SVASVYDGKL
350
LIGTLYHRAL
YCEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0102007 | acyl-L-homoserine-lactone lactonohydrolase activity |
| Molecular Function | GO:0004064 | arylesterase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:1901335 | lactone catabolic process |
| Biological Process | GO:0009636 | response to toxic substance |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.