Search Results
Overview
| Uniprot ID | Q15166 |
|---|---|
| Protein Name | Serum paraoxonase/lactonase 3 |
| Gene Name | PON3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 159 | LVYLKTIKHELLKSV |
| 313 | IQNVLSEKPRVSTVY |
Function
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents
Protein Sequence
10
MGKLVALVLL
20
GVGLSLVGEM
30
FLAFRERVNA
40
SREVEPVEPE
50
NCHLIEELES
60
GSEDIDILPS
70
GLAFISSGLK
80
YPGMPNFAPD
90
EPGKIFLMDL
100
NEQNPRAQAL
110
EISGGFDKEL
120
FNPHGISIFI
130
DKDNTVYLYV
140
VNHPHMKSTV
150
EIFKFEEQQR
160
SLVYLKTIKH
170
ELLKSVNDIV
180
VLGPEQFYAT
190
RDHYFTNSLL
200
SFFEMILDLR
210
WTYVLFYSPR
220
EVKVVAKGFC
230
SANGITVSAD
240
QKYVYVADVA
250
AKNIHIMEKH
260
DNWDLTQLKV
270
IQLGTLVDNL
280
TVDPATGDIL
290
AGCHPNPMKL
300
LNYNPEDPPG
310
SEVLRIQNVL
320
SEKPRVSTVY
330
ANNGSVLQGT
340
SVASVYHGKI
350
LIGTVFHKTL
YCEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0102007 | acyl-L-homoserine-lactone lactonohydrolase activity |
| Molecular Function | GO:0004063 | aryldialkylphosphatase activity |
| Molecular Function | GO:0004064 | arylesterase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0046395 | carboxylic acid catabolic process |
| Biological Process | GO:1901335 | lactone catabolic process |
| Biological Process | GO:0032929 | negative regulation of superoxide anion generation |
| Biological Process | GO:2001038 | regulation of cellular response to drug |
| Biological Process | GO:0009636 | response to toxic substance |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.