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Overview

Uniprot IDQ15170
Protein NameTranscription elongation factor A protein-like 1
Gene NameTCEAL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
94 QPPCGVGKHKLEEGS
96 PCGVGKHKLEEGSFK

Function

May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly

Protein Sequence

10 MDKPRKENEE 20 EPQSAPKTDE 30 ERPPVEHSPE 40 KQSPEEQSSE 50 EQSSEEEFFP 60 EELLPELLPE 70 MLLSEERPPQ 80 EGLSRKDLFE 90 GRPPMEQPPC 100 GVGKHKLEEG 110 SFKERLARSR 120 PQFRGDIHGR 130 NLSNEEMIQA 140 ADELEEMKRV 150 RNKLMIMHWK AKRSRPYPI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.