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Overview

Uniprot IDQ15181
Protein NameInorganic pyrophosphatase
Gene NamePPA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
128 DVCEIGSKVCARGEI
194 VDWFRRYKVPDGKPE
199 RYKVPDGKPENEFAF
221 DFAIDIIKSTHDHWK
228 KSTHDHWKALVTKKT
238 VTKKTNGKGISCMNT
25 RVFLKNEKGQYISPF
57 VPRWSNAKMEIATKD
63 AKMEIATKDPLNPIK
70 KDPLNPIKQDVKKGK

Function

Catalyzes the hydrolysis of inorganic diphosphate into two phosphate molecules (PubMed:33036755, PubMed:38428647). Has MAP kinase serine/threonine phosphatase activity toward c-Jun N-terminal kinase (JNK) and, in neuronal cells, is involved in the negative regulation of neurite growth via JNK dephosphorylation (By similarity)

Protein Sequence

10 MSGFSTEERA 20 APFSLEYRVF 30 LKNEKGQYIS 40 PFHDIPIYAD 50 KDVFHMVVEV 60 PRWSNAKMEI 70 ATKDPLNPIK 80 QDVKKGKLRY 90 VANLFPYKGY 100 IWNYGAIPQT 110 WEDPGHNDKH 120 TGCCGDNDPI 130 DVCEIGSKVC 140 ARGEIIGVKV 150 LGILAMIDEG 160 ETDWKVIAIN 170 VDDPDAANYN 180 DINDVKRLKP 190 GYLEATVDWF 200 RRYKVPDGKP 210 ENEFAFNAEF 220 KDKDFAIDII 230 KSTHDHWKAL 240 VTKKTNGKGI 250 SCMNTTLSES 260 PFKCDPDAAR 270 AIVDALPPPC 280 ESACTVPTDV DKWFHHQKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004427 inorganic diphosphate phosphatase activity
Molecular Function GO:0000287 magnesium ion binding
Biological Process GO:0006796 phosphate-containing compound metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.