Search Results
Overview
| Uniprot ID | Q15185 |
|---|---|
| Protein Name | Prostaglandin E synthase 3 |
| Gene Name | PTGES3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 33 | DVNVNFEKSKLTFSC |
| 35 | NVNFEKSKLTFSCLG |
| 65 | CIDPNDSKHKRTDRS |
| 79 | SILCCLRKGESGQSW |
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0101031 | protein folding chaperone complex |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005697 | telomerase holoenzyme complex |
| Molecular Function | GO:0070182 | DNA polymerase binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0050220 | prostaglandin-E synthase activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0003720 | telomerase activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0051131 | chaperone-mediated protein complex assembly |
| Biological Process | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:0046457 | prostanoid biosynthetic process |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:1905323 | telomerase holoenzyme complex assembly |
| Biological Process | GO:0000723 | telomere maintenance |
| Biological Process | GO:0007004 | telomere maintenance via telomerase |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[6] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.
[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.