Overview
| Uniprot ID | Q15257 |
|---|
| Protein Name | Serine/threonine-protein phosphatase 2A activator |
|---|
| Gene Name | PTPA |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 337 |
YKAECLEKFPVIQHF |
Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (PubMed:16916641, PubMed:36073231). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase (PubMed:16916641). Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro) (PubMed:16916641). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex (PubMed:16916641). Is involved in apoptosis; the function appears to be independent from PP2A (PubMed:17333320)
Protein Sequence
10
MAEGERQPPP
20
DSSEEAPPAT
30
QNFIIPKKEI
40
HTVPDMGKWK
50
RSQAYADYIG
60
FILTLNEGVK
70
GKKLTFEYRV
80
SEMWNEVHEE
90
KEQAAKQSVS
100
CDECIPLPRA
110
GHCAPSEAIE
120
KLVALLNTLD
130
RWIDETPPVD
140
QPSRFGNKAY
150
RTWYAKLDEE
160
AENLVATVVP
170
THLAAAVPEV
180
AVYLKESVGN
190
STRIDYGTGH
200
EAAFAAFLCC
210
LCKIGVLRVD
220
DQIAIVFKVF
230
NRYLEVMRKL
240
QKTYRMEPAG
250
SQGVWGLDDF
260
QFLPFIWGSS
270
QLIDHPYLEP
280
RHFVDEKAVN
290
ENHKDYMFLE
300
CILFITEMKT
310
GPFAEHSNQL
320
WNISAVPSWS
330
KVNQGLIRMY
340
KAECLEKFPV
350
IQHFKFGSLL
PIHPVTSG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:1904949 |
ATPase complex |
| Cellular Component |
GO:0034704 |
calcium channel complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000159 |
protein phosphatase type 2A complex |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function |
GO:0019902 |
phosphatase binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0051721 |
protein phosphatase 2A binding |
| Molecular Function |
GO:0019888 |
protein phosphatase regulator activity |
| Molecular Function |
GO:0008160 |
protein tyrosine phosphatase activator activity |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Biological Process |
GO:0007052 |
mitotic spindle organization |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
Reference
PMID: N/A