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Overview

Uniprot IDQ15269
Protein NamePeriodic tryptophan protein 2 homolog
Gene NamePWP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
596 TGRKELDKITAKHAA
600 ELDKITAKHAAKGKA

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

Protein Sequence

10 MKFAYRFSNL 20 LGTVYRRGNL 30 NFTCDGNSVI 40 SPVGNRVTVF 50 DLKNNKSDTL 60 PLATRYNVKC 70 VGLSPDGRLA 80 IIVDEGGDAL 90 LVSLVCRSVL 100 HHFHFKGSVH 110 SVSFSPDGRK 120 FVVTKGNIAQ 130 MYHAPGKKRE 140 FNAFVLDKTY 150 FGPYDETTCI 160 DWTDDSRCFV 170 VGSKDMSTWV 180 FGAERWDNLI 190 YYALGGHKDA 200 IVACFFESNS 210 LDLYSLSQDG 220 VLCMWQCDTP 230 PEGLRLKPPA 240 GWKADLLQRE 250 EEEEEEEDQE 260 GDRETTIRGK 270 ATPAEEEKTG 280 KVKYSRLAKY 290 FFNKEGDFNN 300 LTAAAFHKKS 310 HLLVTGFASG 320 IFHLHELPEF 330 NLIHSLSISD 340 QSIASVAINS 350 SGDWIAFGCS 360 GLGQLLVWEW 370 QSESYVLKQQ 380 GHFNSMVALA 390 YSPDGQYIVT 400 GGDDGKVKVW 410 NTLSGFCFVT 420 FTEHSSGVTG 430 VTFTATGYVV 440 VTSSMDGTVR 450 AFDLHRYRNF 460 RTFTSPRPTQ 470 FSCVAVDASG 480 EIVSAGAQDS 490 FEIFVWSMQT 500 GRLLDVLSGH 510 EGPISGLCFN 520 PMKSVLASAS 530 WDKTVRLWDM 540 FDSWRTKETL 550 ALTSDALAVT 560 FRPDGAELAV 570 ATLNSQITFW 580 DPENAVQTGS 590 IEGRHDLKTG 600 RKELDKITAK 610 HAAKGKAFTA 620 LCYSADGHSI 630 LAGGMSKFVC 640 IYHVREQILM 650 KRFEISCNLS 660 LDAMEEFLNR 670 RKMTEFGNLA 680 LIDQDAGQED 690 GVAIPLPGVR 700 KGDMSSRHFK 710 PEIRVTSLRF 720 SPTGRCWAAT 730 TTEGLLIYSL 740 DTRVLFDPFE 750 LDTSVTPGRV 760 REALRQQDFT 770 RAILMALRLN 780 ESKLVQEALE 790 AVPRGEIEVV 800 TSSLPELYVE 810 KVLEFLASSF 820 EVSRHLEFYL 830 LWTHKLLMLH 840 GQKLKSRAGT 850 LLPVIQFLQK 860 SIQRHLDDLS 870 KLCSWNHYNM 880 QYALAVSKQR 890 GTKRSLDPLG 900 SEEEAEASED 910 DSLHLLGGGG RDSEEEMLA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0003723 RNA binding
Biological Process GO:0030490 maturation of SSU-rRNA
Biological Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000028 ribosomal small subunit assembly
Biological Process GO:0042274 ribosomal small subunit biogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.