Search Results

Overview

Uniprot IDQ15274
Protein NameNicotinate-nucleotide pyrophosphorylase [carboxylating]
Gene NameQPRT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
139 GHVAGTRKTTPGFRL
149 PGFRLVEKYGLLVGG
171 LGGLVMVKDNHVVAA
183 VAAGGVEKAVRAARQ
288 FSLKLFAKEVAPVPK
295 KEVAPVPKIH*****

Function

Involved in the catabolism of quinolinic acid (QA)

Protein Sequence

10 MDAEGLALLL 20 PPVTLAALVD 30 SWLREDCPGL 40 NYAALVSGAG 50 PSQAALWAKS 60 PGVLAGQPFF 70 DAIFTQLNCQ 80 VSWFLPEGSK 90 LVPVARVAEV 100 RGPAHCLLLG 110 ERVALNTLAR 120 CSGIASAAAA 130 AVEAARGAGW 140 TGHVAGTRKT 150 TPGFRLVEKY 160 GLLVGGAASH 170 RYDLGGLVMV 180 KDNHVVAAGG 190 VEKAVRAARQ 200 AADFTLKVEV 210 ECSSLQEAVQ 220 AAEAGADLVL 230 LDNFKPEELH 240 PTATVLKAQF 250 PSVAVEASGG 260 ITLDNLPQFC 270 GPHIDVISMG 280 MLTQAAPALD 290 FSLKLFAKEV APVPKIH

Gene Ontology

Classification GO ID Description
Cellular Component GO:1902494 catalytic complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
Biological Process GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan
Biological Process GO:0009435 NAD+ biosynthetic process
Biological Process GO:0034213 quinolinate catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.