Search Results
Overview
| Uniprot ID | Q15276 |
|---|---|
| Protein Name | Rab GTPase-binding effector protein 1 |
| Gene Name | RABEP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 429 | LGYNYKAKSAGNLDE |
Function
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Forms a complex with RABGEF1 that stimulates RABGEF1-mediated nucleotide exchange on RAB5A (PubMed:9323142). Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity)
Protein Sequence
10
MAQPGPASQP
20
DVSLQQRVAE
30
LEKINAEFLR
40
AQQQLEQEFN
50
QKRAKFKELY
60
LAKEEDLKRQ
70
NAVLQAAQDD
80
LGHLRTQLWE
90
AQAEMENIKA
100
IATVSENTKQ
110
EAIDEVKRQW
120
REEVASLQAV
130
MKETVRDYEH
140
QFHLRLEQER
150
TQWAQYRESA
160
EREIADLRRR
170
LSEGQEEENL
180
ENEMKKAQED
190
AEKLRSVVMP
200
MEKEIAALKD
210
KLTEAEDKIK
220
ELEASKVKEL
230
NHYLEAEKSC
240
RTDLEMYVAV
250
LNTQKSVLQE
260
DAEKLRKELH
270
EVCHLLEQER
280
QQHNQLKHTW
290
QKANDQFLES
300
QRLLMRDMQR
310
MEIVLTSEQL
320
RQVEELKKKD
330
QEDDEQQRLN
340
KRKDHKKADV
350
EEEIKIPVVC
360
ALTQEESSAQ
370
LSNEEEHLDS
380
TRGSVHSLDA
390
GLLLPSGDPF
400
SKSDNDMFKD
410
GLRRAQSTDS
420
LGTSGSLQSK
430
ALGYNYKAKS
440
AGNLDESDFG
450
PLVGADSVSE
460
NFDTASLGSL
470
QMPSGFMLTK
480
DQERAIKAMT
490
PEQEETASLL
500
SSVTQGMESA
510
YVSPSGYRLV
520
SETEWNLLQK
530
EVHNAGNKLG
540
RRCDMCSNYE
550
KQLQGIQIQE
560
AETRDQVKKL
570
QLMLRQANDQ
580
LEKTMKDKQE
590
LEDFIKQSSE
600
DSSHQISALV
610
LRAQASEILL
620
EELQQGLSQA
630
KRDVQEQMAV
640
LMQSREQVSE
650
ELVRLQKDND
660
SLQGKHSLHV
670
SLQQAEDFIL
680
PDTTEALREL
690
VLKYREDIIN
700
VRTAADHVEE
710
KLKAEILFLK
720
EQIQAEQCLK
730
ENLEETLQLE
740
IENCKEEIAS
750
ISSLKAELER
760
IKVEKGQLES
770
TLREKSQQLE
780
SLQEIKISLE
790
EQLKKETAAK
800
ATVEQLMFEE
810
KNKAQRLQTE
820
LDVSEQVQRD
830
FVKLSQTLQV
840
QLERIRQADS
850
LERIRAILND
860
TKLTDINQLP
ET
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0055037 | recycling endosome |
| Molecular Function | GO:0008083 | growth factor activity |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0006893 | Golgi to plasma membrane transport |
| Biological Process | GO:0061025 | membrane fusion |
| Biological Process | GO:1903441 | protein localization to ciliary membrane |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.