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Overview

Uniprot ID	Q15311
Protein Name	RalA-binding protein 1
Gene Name	RALBP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
107	PSKMKRSKGIHVFKK

Function

Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277)

Protein Sequence

10 MTECFLPPTS 20 SPSEHRRVEH 30 GSGLTRTPSS 40 EEISPTKFPG 50 LYRTGEPSPP 60 HDILHEPPDV 70 VSDDEKDHGK 80 KKGKFKKKEK 90 RTEGYAAFQE 100 DSSGDEAESP 110 SKMKRSKGIH 120 VFKKPSFSKK 130 KEKDFKIKEK 140 PKEEKHKEEK 150 HKEEKHKEKK 160 SKDLTAADVV 170 KQWKEKKKKK 180 KPIQEPEVPQ 190 IDVPNLKPIF 200 GIPLADAVER 210 TMMYDGIRLP 220 AVFRECIDYV 230 EKYGMKCEGI 240 YRVSGIKSKV 250 DELKAAYDRE 260 ESTNLEDYEP 270 NTVASLLKQY 280 LRDLPENLLT 290 KELMPRFEEA 300 CGRTTETEKV 310 QEFQRLLKEL 320 PECNYLLISW 330 LIVHMDHVIA 340 KELETKMNIQ 350 NISIVLSPTV 360 QISNRVLYVF 370 FTHVQELFGN 380 VVLKQVMKPL 390 RWSNMATMPT 400 LPETQAGIKE 410 EIRRQEFLLN 420 CLHRDLQGGI 430 KDLSKEERLW 440 EVQRILTALK 450 RKLREAKRQE 460 CETKIAQEIA 470 SLSKEDVSKE 480 EMNENEEVIN 490 ILLAQENEIL 500 TEQEELLAME 510 QFLRRQIASE 520 KEEIERLRAE 530 IAEIQSRQQH 540 GRSETEEYSS 550 ESESESEDEE 560 ELQIILEDLQ 570 RQNEELEIKN 580 NHLNQAIHEE 590 REAIIELRVQ 600 LRLLQMQRAK 610 AEQQAQEDEE 620 PEWRGGAVQP 630 PRDGVLEPKA 640 AKEQPKAGKE 650 PAKPSPSRDR KETSI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0000922	spindle pole
Molecular Function	GO:0015431	ABC-type glutathione S-conjugate transporter activity
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0031267	small GTPase binding
Molecular Function	GO:0022857	transmembrane transporter activity
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity
Biological Process	GO:0006935	chemotaxis
Biological Process	GO:1900753	doxorubicin transport
Biological Process	GO:0043547	positive regulation of GTPase activity
Biological Process	GO:0090141	positive regulation of mitochondrial fission
Biological Process	GO:0001934	positive regulation of protein phosphorylation
Biological Process	GO:0006898	receptor-mediated endocytosis
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction
Biological Process	GO:0043087	regulation of GTPase activity
Biological Process	GO:0051056	regulation of small GTPase mediated signal transduction
Biological Process	GO:0007264	small GTPase-mediated signal transduction
Biological Process	GO:0055085	transmembrane transport
Biological Process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.