Search Results
Overview
| Uniprot ID | Q15326 |
|---|---|
| Protein Name | Zinc finger MYND domain-containing protein 11 |
| Gene Name | ZMYND11 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 479 | TKIFNDFKDRMKSDH |
Function
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth
Protein Sequence
10
MARLTKRRQA
20
DTKAIQHLWA
30
AIEIIRNQKQ
40
IANIDRITKY
50
MSRVHGMHPK
60
ETTRQLSLAV
70
KDGLIVETLT
80
VGCKGSKAGI
90
EQEGYWLPGD
100
EIDWETENHD
110
WYCFECHLPG
120
EVLICDLCFR
130
VYHSKCLSDE
140
FRLRDSSSPW
150
QCPVCRSIKK
160
KNTNKQEMGT
170
YLRFIVSRMK
180
ERAIDLNKKG
190
KDNKHPMYRR
200
LVHSAVDVPT
210
IQEKVNEGKY
220
RSYEEFKADA
230
QLLLHNTVIF
240
YGADSEQADI
250
ARMLYKDTCH
260
ELDELQLCKN
270
CFYLSNARPD
280
NWFCYPCIPN
290
HELVWAKMKG
300
FGFWPAKVMQ
310
KEDNQVDVRF
320
FGHHHQRAWI
330
PSENIQDITV
340
NIHRLHVKRS
350
MGWKKACDEL
360
ELHQRFLREG
370
RFWKSKNEDR
380
GEEEAESSIS
390
STSNEQLKVT
400
QEPRAKKGRR
410
NQSVEPKKEE
420
PEPETEAVSS
430
SQEIPTMPQP
440
IEKVSVSTQT
450
KKLSASSPRM
460
LHRSTQTTND
470
GVCQSMCHDK
480
YTKIFNDFKD
490
RMKSDHKRET
500
ERVVREALEK
510
LRSEMEEEKR
520
QAVNKAVANM
530
QGEMDRKCKQ
540
VKEKCKEEFV
550
EEIKKLATQH
560
KQLISQTKKK
570
QWCYNCEEEA
580
MYHCCWNTSY
590
CSIKCQQEHW
600
HAEHKRTCRR
KR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0140003 | histone H3K36me3 reader activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0051607 | defense response to virus |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:0009966 | regulation of signal transduction |
| Biological Process | GO:0034243 | regulation of transcription elongation by RNA polymerase II |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.