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Overview

Uniprot IDQ15345
Protein NameLeucine-rich repeat-containing protein 41
Gene NameLRRC41
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
355 SHEAPGTKRSPSAPA
375 SSSTSSYKRAPASSA
389 APQPKPLKRFKRAAG

Function

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Protein Sequence

10 MAAPEAWRAR 20 SCWFCEVAAA 30 TTMEATSREA 40 APAKSSASGP 50 NAPPALFELC 60 GRAVSAHMGV 70 LESGVWALPG 80 PILQSILPLL 90 NIYYLERIEE 100 TALKKGLSTQ 110 AIWRRLWDEL 120 MKTRPSSLES 130 VTCWRAKFME 140 AFFSHVLRGT 150 IDVSSDRRLC 160 DQRFSPLLHS 170 SRHVRQLTIC 180 NMLQGATELV 190 AEPNRRVLET 200 LASSLHTLKF 210 RHLLFSDVAA 220 QQSLRQLLHQ 230 LIHHGAVSQV 240 SLYSWPVPES 250 ALFILILTMS 260 AGFWQPGPGG 270 PPCRLCGEAS 280 RGRAPSRDEG 290 SLLLGSRRPR 300 RDAAERCAAA 310 LMASRRKSEA 320 KQMPRAAPAT 330 RVTRRSTQES 340 LTAGGTDLKR 350 ELHPPATSHE 360 APGTKRSPSA 370 PAATSSASSS 380 TSSYKRAPAS 390 SAPQPKPLKR 400 FKRAAGKKGA 410 RTRQGPGAES 420 EDLYDFVFIV 430 AGEKEDGEEM 440 EIGEVACGAL 450 DGSDPSCLGL 460 PALEASQRFR 470 SISTLELFTV 480 PLSTEAALTL 490 CHLLSSWVSL 500 ESLTLSYNGL 510 GSNIFRLLDS 520 LRALSGQAGC 530 RLRALHLSDL 540 FSPLPILELT 550 RAIVRALPLL 560 RVLSIRVDHP 570 SQRDNPGVPG 580 NAGPPSHIIG 590 DEEIPENCLE 600 QLEMGFPRGA 610 QPAPLLCSVL 620 KASGSLQQLS 630 LDSATFASPQ 640 DFGLVLQTLK 650 EYNLALKRLS 660 FHDMNLADCQ 670 SEVLFLLQNL 680 TLQEITFSFC 690 RLFEKRPAQF 700 LPEMVAAMKG 710 NSTLKGLRLP 720 GNRLGNAGLL 730 ALADVFSEDS 740 SSSLCQLDIS 750 SNCIKPDGLL 760 EFAKRLERWG 770 RGAFGHLRLF 780 QNWLDQDAVT 790 AREAIRRLRA 800 TCHVVSDSWD 810 SSQAFADYVS TM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0016567 protein ubiquitination

Reference

PMID: N/A