Search Results

Overview

Uniprot ID	Q15365
Protein Name	Poly(rC)-binding protein 1
Gene Name	PCBP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
115	QCGSLIGKGGCKIKE
119	LIGKGGCKIKEIRES
160	QSVTECVKQICLVML
23	IRLLMHGKEVGSIIG
31	EVGSIIGKKGESVKR
32	VGSIIGKKGESVKRI
351	NARLSSEKGMGCS**
78	AFAMIIDKLEEDINS

Function

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity)

Protein Sequence

10 MDAGVTESGL 20 NVTLTIRLLM 30 HGKEVGSIIG 40 KKGESVKRIR 50 EESGARINIS 60 EGNCPERIIT 70 LTGPTNAIFK 80 AFAMIIDKLE 90 EDINSSMTNS 100 TAASRPPVTL 110 RLVVPATQCG 120 SLIGKGGCKI 130 KEIRESTGAQ 140 VQVAGDMLPN 150 STERAITIAG 160 VPQSVTECVK 170 QICLVMLETL 180 SQSPQGRVMT 190 IPYQPMPASS 200 PVICAGGQDR 210 CSDAAGYPHA 220 THDLEGPPLD 230 AYSIQGQHTI 240 SPLDLAKLNQ 250 VARQQSHFAM 260 MHGGTGFAGI 270 DSSSPEVKGY 280 WASLDASTQT 290 THELTIPNNL 300 IGCIIGRQGA 310 NINEIRQMSG 320 AQIKIANPVE 330 GSSGRQVTIT 340 GSAASISLAQ 350 YLINARLSSE KGMGCS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0098847	sequence-specific single stranded DNA binding
Molecular Function	GO:0003697	single-stranded DNA binding
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0039694	viral RNA genome replication

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[8] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[9] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[10] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[11] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[12] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[13] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.