Search Results
Overview
| Uniprot ID | Q15369 |
|---|---|
| Protein Name | Elongin-C |
| Gene Name | ELOC |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 32 | DGHEFIVKREHALTS |
Function
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0031462 | Cul2-RING ubiquitin ligase complex |
| Cellular Component | GO:0031466 | Cul5-RING ubiquitin ligase complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070449 | elongin complex |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Biological Process | GO:2000104 | negative regulation of DNA-templated DNA replication |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:1990116 | ribosome-associated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0140958 | target-directed miRNA degradation |
| Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0140627 | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.