Search Results
Overview
| Uniprot ID | Q15370 |
|---|---|
| Protein Name | Elongin-B |
| Gene Name | ELOB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | PELPDVMKPQDSGSS |
| 11 | FLMIRRHKTTIFTDA |
| 55 | DQLLDDGKTLGECGF |
Function
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031462 | Cul2-RING ubiquitin ligase complex |
| Cellular Component | GO:0031466 | Cul5-RING ubiquitin ligase complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070449 | elongin complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0030891 | VCB complex |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:2000104 | negative regulation of DNA-templated DNA replication |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:1990116 | ribosome-associated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0140958 | target-directed miRNA degradation |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
| Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
| Biological Process | GO:0140627 | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.