Search Results

Overview

Uniprot ID	Q15392
Protein Name	Delta(24)-sterol reductase
Gene Name	DHCR24
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
313	KHVENYLKTNREGLE
367	PPKISLLKLTQGETL
376	TQGETLRKLYEQHHV
496	LYHKLREKLGCQDAF
76	QRVRDIQKQVREWKE

Function

Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:22178193, PubMed:25637936). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892)

Protein Sequence

10 MEPAVSLAVC 20 ALLFLLWVRL 30 KGLEFVLIHQ 40 RWVFVCLFLL 50 PLSLIFDIYY 60 YVRAWVVFKL 70 SSAPRLHEQR 80 VRDIQKQVRE 90 WKEQGSKTFM 100 CTGRPGWLTV 110 SLRVGKYKKT 120 HKNIMINLMD 130 ILEVDTKKQI 140 VRVEPLVTMG 150 QVTALLTSIG 160 WTLPVLPELD 170 DLTVGGLIMG 180 TGIESSSHKY 190 GLFQHICTAY 200 ELVLADGSFV 210 RCTPSENSDL 220 FYAVPWSCGT 230 LGFLVAAEIR 240 IIPAKKYVKL 250 RFEPVRGLEA 260 ICAKFTHESQ 270 RQENHFVEGL 280 LYSLDEAVIM 290 TGVMTDEAEP 300 SKLNSIGNYY 310 KPWFFKHVEN 320 YLKTNREGLE 330 YIPLRHYYHR 340 HTRSIFWELQ 350 DIIPFGNNPI 360 FRYLFGWMVP 370 PKISLLKLTQ 380 GETLRKLYEQ 390 HHVVQDMLVP 400 MKCLQQALHT 410 FQNDIHVYPI 420 WLCPFILPSQ 430 PGLVHPKGNE 440 AELYIDIGAY 450 GEPRVKHFEA 460 RSCMRQLEKF 470 VRSVHGFQML 480 YADCYMNREE 490 FWEMFDGSLY 500 HKLREKLGCQ 510 DAFPEVYDKI CKAARH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0000246	Delta24(24-1) sterol reductase activity
Molecular Function	GO:0050614	Delta24-sterol reductase activity
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0071949	FAD binding
Molecular Function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Molecular Function	GO:0042605	peptide antigen binding
Biological Process	GO:0006695	cholesterol biosynthetic process
Biological Process	GO:0033489	cholesterol biosynthetic process via desmosterol
Biological Process	GO:0033490	cholesterol biosynthetic process via lathosterol
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0007265	Ras protein signal transduction
Biological Process	GO:0009725	response to hormone
Biological Process	GO:0043588	skin development
Biological Process	GO:0008202	steroid metabolic process
Biological Process	GO:0009888	tissue development

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.