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Overview

Uniprot IDQ15404
Protein NameRas suppressor protein 1
Gene NameRSU1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
158 PDIGKLTKLQILSLR
7 *MSKSLKKLVEESRE

Function

Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro

Protein Sequence

10 MSKSLKKLVE 20 ESREKNQPEV 30 DMSDRGISNM 40 LDVNGLFTLS 50 HITQLVLSHN 60 KLTMVPPNIA 70 ELKNLEVLNF 80 FNNQIEELPT 90 QISSLQKLKH 100 LNLGMNRLNT 110 LPRGFGSLPA 120 LEVLDLTYNN 130 LSENSLPGNF 140 FYLTTLRALY 150 LSDNDFEILP 160 PDIGKLTKLQ 170 ILSLRDNDLI 180 SLPKEIGELT 190 QLKELHIQGN 200 RLTVLPPELG 210 NLDLTGQKQV 220 FKAENNPWVT 230 PIADQFQLGV 240 SHVFEYIRSE 250 TYKYLYGRHM 260 QANPEPPKKN 270 NDKSKKISRK PLAAKNR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0007165 signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.