Search Results

Overview

Uniprot IDQ15413
Protein NameRyanodine receptor 3
Gene NameRYR3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
3613 EKEMEKQKTLYQQAR

Function

Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction (PubMed:12354756, PubMed:9395096). May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling

Protein Sequence

10 MAEGGEGGED 20 EIQFLRTEDE 30 VVLQCIATIH 40 KEQRKFCLAA 50 EGLGNRLCFL 60 EPTSEAKYIP 70 PDLCVCNFVL 80 EQSLSVRALQ 90 EMLANTGENG 100 GEGAAQGGGH 110 RTLLYGHAVL 120 LRHSFSGMYL 130 TCLTTSRSQT 140 DKLAFDVGLR 150 EHATGEACWW 160 TIHPASKQRS 170 EGEKVRIGDD 180 LILVSVSSER 190 YLHLSVSNGN 200 IQVDASFMQT 210 LWNVHPTCSG 220 SSIEEGYLLG 230 GHVVRLFHGH 240 DECLTIPSTD 250 QNDSQHRRIF 260 YEAGGAGTRA 270 RSLWRVEPLR 280 ISWSGSNIRW 290 GQAFRLRHLT 300 TGHYLALTED 310 QGLILQDRAK 320 SDTKSTAFSF 330 RASKELKEKL 340 DSSHKRDIEG 350 MGVPEIKYGD 360 SVCFVQHIAS 370 GLWVTYKAQD 380 AKTSRLGPLK 390 RKVILHQEGH 400 MDDGLTLQRC 410 QREESQAARI 420 IRNTTALFSQ 430 FVSGNNRTAA 440 PITLPIEEVL 450 QTLQDLIAYF 460 QPPEEEMRHE 470 DKQNKLRSLK 480 NRQNLFKEEG 490 MLALVLNCID 500 RLNVYNSVAH 510 FAGIAREESG 520 MAWKEILNLL 530 YKLLAALIRG 540 NRNNCAQFSN 550 NLDWLISKLD 560 RLESSSGILE 570 VLHCILTESP 580 EALNLIAEGH 590 IKSIISLLDK 600 HGRNHKVLDI 610 LCSLCLCNGV 620 AVRANQNLIC 630 DNLLPRRNLL 640 LQTRLINDVT 650 SIRPNIFLGV 660 AEGSAQYKKW 670 YFELIIDQVD 680 PFLTAEPTHL 690 RVGWASSSGY 700 APYPGGGEGW 710 GGNGVGDDLY 720 SYGFDGLHLW 730 SGRIPRAVAS 740 INQHLLRSDD 750 VVSCCLDLGV 760 PSISFRINGQ 770 PVQGMFENFN 780 TDGLFFPVMS 790 FSAGVKVRFL 800 MGGRHGEFKF 810 LPPSGYAPCY 820 EALLPKEKMR 830 LEPVKEYKRD 840 ADGIRDLLGT 850 TQFLSQASFI 860 PCPVDTSQVI 870 LPPHLEKIRD 880 RLAENIHELW 890 GMNKIELGWT 900 FGKIRDDNKR 910 QHPCLVEFSK 920 LPETEKNYNL 930 QMSTETLKTL 940 LALGCHIAHV 950 NPAAEEDLKK 960 VKLPKNYMMS 970 NGYKPAPLDL 980 SDVKLLPPQE 990 ILVDKLAENA 1000 HNVWAKDRIK 1010 QGWTYGIQQD 1020 LKNKRNPRLV 1030 PYALLDERTK 1040 KSNRDSLREA 1050 VRTFVGYGYN 1060 IEPSDQELAD 1070 SAVEKVSIDK 1080 IRFFRVERSY 1090 AVRSGKWYFE 1100 FEVVTGGDMR 1110 VGWARPGCRP 1120 DVELGADDQA 1130 FVFEGNRGQR 1140 WHQGSGYFGR 1150 TWQPGDVVGC 1160 MINLDDASMI 1170 FTLNGELLIT 1180 NKGSELAFAD 1190 YEIENGFVPI 1200 CCLGLSQIGR 1210 MNLGTDASTF 1220 KFYTMCGLQE 1230 GFEPFAVNMN 1240 RDVAMWFSKR 1250 LPTFVNVPKD 1260 HPHIEVMRID 1270 GTMDSPPCLK 1280 VTHKTFGTQN 1290 SNADMIYCRL 1300 SMPVECHSSF 1310 SHSPCLDSEA 1320 FQKRKQMQEI 1330 LSHTTTQCYY 1340 AIRIFAGQDP 1350 SCVWVGWVTP 1360 DYHLYSEKFD 1370 LNKNCTVTVT 1380 LGDERGRVHE 1390 SVKRSNCYMV 1400 WGGDIVASSQ 1410 RSNRSNVDLE 1420 IGCLVDLAMG 1430 MLSFSANGKE 1440 LGTCYQVEPN 1450 TKVFPAVFLQ 1460 PTSTSLFQFE 1470 LGKLKNAMPL 1480 SAAIFRSEEK 1490 NPVPQCPPRL 1500 DVQTIQPVLW 1510 SRMPNSFLKV 1520 ETERVSERHG 1530 WVVQCLEPLQ 1540 MMALHIPEEN 1550 RCVDILELCE 1560 QEDLMRFHYH 1570 TLRLYSAVCA 1580 LGNSRVAYAL 1590 CSHVDLSQLF 1600 YAIDNKYLPG 1610 LLRSGFYDLL 1620 ISIHLASAKE 1630 RKLMMKNEYI 1640 IPITSTTRNI 1650 RLFPDESKRH 1660 GLPGVGLRTC 1670 LKPGFRFSTP 1680 CFVVTGEDHQ 1690 KQSPEIPLES 1700 LRTKALSMLT 1710 EAVQCSGAHI 1720 RDPVGGSVEF 1730 QFVPVLKLIG 1740 TLLVMGVFDD 1750 DDVRQILLLI 1760 DPSVFGEHSA 1770 GTEEGAEKEE 1780 VTQVEEKAVE 1790 AGEKAGKEAP 1800 VKGLLQTRLP 1810 ESVKLQMCEL 1820 LSYLCDCELQ 1830 HRVEAIVAFG 1840 DIYVSKLQAN 1850 QKFRYNELMQ 1860 ALNMSAALTA 1870 RKTKEFRSPP 1880 QEQINMLLNF 1890 QLGENCPCPE 1900 EIREELYDFH 1910 EDLLLHCGVP 1920 LEEEEEEEED 1930 TSWTGKLCAL 1940 VYKIKGPPKP 1950 EKEQPTEEEE 1960 RCPTTLKELI 1970 SQTMICWAQE 1980 DQIQDSELVR 1990 MMFNLLRRQY 2000 DSIGELLQAL 2010 RKTYTISHTS 2020 VSDTINLLAA 2030 LGQIRSLLSV 2040 RMGKEEELLM 2050 INGLGDIMNN 2060 KVFYQHPNLM 2070 RVLGMHETVM 2080 EVMVNVLGTE 2090 KSQIAFPKMV 2100 ASCCRFLCYF 2110 CRISRQNQKA 2120 MFEHLSYLLE 2130 NSSVGLASPS 2140 MRGSTPLDVA 2150 ASSVMDNNEL 2160 ALSLEEPDLE 2170 KVVTYLAGCG 2180 LQSCPMLLAK 2190 GYPDVGWNPI 2200 EGERYLSFLR 2210 FAVFVNSESV 2220 EENASVVVKL 2230 LIRRPECFGP 2240 ALRGEGGNGL 2250 LAAMQGAIKI 2260 SENPALDLPS 2270 QGYKREVSTG 2280 DDEEEEEIVH 2290 MGNAIMSFYS 2300 ALIDLLGRCA 2310 PEMHLIQTGK 2320 GEAIRIRSIL 2330 RSLVPTEDLV 2340 GIISIPLKLP 2350 SLNKDGSVSE 2360 PDMAANFCPD 2370 HKAPMVLFLD 2380 RVYGIKDQTF 2390 LLHLLEVGFL 2400 PDLRASASLD 2410 TVSLSTTEAA 2420 LALNRYICSA 2430 VLPLLTRCAP 2440 LFAGTEHCTS 2450 LIDSTLQTIY 2460 RLSKGRSLTK 2470 AQRDTIEECL 2480 LAICNHLRPS 2490 MLQQLLRRLV 2500 FDVPQLNEYC 2510 KMPLKLLTNH 2520 YEQCWKYYCL 2530 PSGWGSYGLA 2540 VEEELHLTEK 2550 LFWGIFDSLS 2560 HKKYDPDLFR 2570 MALPCLSAIA 2580 GALPPDYLDT 2590 RITATLEKQI 2600 SVDADGNFDP 2610 KPINTMNFSL 2620 PEKLEYIVTK 2630 YAEHSHDKWA 2640 CDKSQSGWKY 2650 GISLDENVKT 2660 HPLIRPFKTL 2670 TEKEKEIYRW 2680 PARESLKTML 2690 AVGWTVERTK 2700 EGEALVQQRE 2710 NEKLRSVSQA 2720 NQGNSYSPAP 2730 LDLSNVVLSR 2740 ELQGMVEVVA 2750 ENYHNIWAKK 2760 KKLELESKGG 2770 GSHPLLVPYD 2780 TLTAKEKFKD 2790 REKAQDLFKF 2800 LQVNGIIVSR 2810 GMKDMELDAS 2820 SMEKRFAYKF 2830 LKKILKYVDS 2840 AQEFIAHLEA 2850 IVSSGKTEKS 2860 PRDQEIKFFA 2870 KVLLPLVDQY 2880 FTSHCLYFLS 2890 SPLKPLSSSG 2900 YASHKEKEMV 2910 AGLFCKLAAL 2920 VRHRISLFGS 2930 DSTTMVSCLH 2940 ILAQTLDTRT 2950 VMKSGSELVK 2960 AGLRAFFENA 2970 AEDLEKTSEN 2980 LKLGKFTHSR 2990 TQIKGVSQNI 3000 NYTTVALLPI 3010 LTSIFEHVTQ 3020 HQFGMDLLLG 3030 DVQISCYHIL 3040 CSLYSLGTGK 3050 NIYVERQRPA 3060 LGECLASLAA 3070 AIPVAFLEPT 3080 LNRYNPLSVF 3090 NTKTPRERSI 3100 LGMPDTVEDM 3110 CPDIPQLEGL 3120 MKEINDLAES 3130 GARYTEMPHV 3140 IEVILPMLCN 3150 YLSYWWERGP 3160 ENLPPSTGPC 3170 CTKVTSEHLS 3180 LILGNILKII 3190 NNNLGIDEAS 3200 WMKRIAVYAQ 3210 PIISKARPDL 3220 LRSHFIPTLE 3230 KLKKKAVKTV 3240 QEEEQLKADG 3250 KGDTQEAELL 3260 ILDEFAVLCR 3270 DLYAFYPMLI 3280 RYVDNNRSNW 3290 LKSPDADSDQ 3300 LFRMVAEVFI 3310 LWCKSHNFKR 3320 EEQNFVIQNE 3330 INNLAFLTGD 3340 SKSKMSKAMQ 3350 VKSGGQDQER 3360 KKTKRRGDLY 3370 SIQTSLIVAA 3380 LKKMLPIGLN 3390 MCTPGDQELI 3400 SLAKSRYSHR 3410 DTDEEVREHL 3420 RNNLHLQEKS 3430 DDPAVKWQLN 3440 LYKDVLKSEE 3450 PFNPEKTVER 3460 VQRISAAVFH 3470 LEQVEQPLRS 3480 KKAVWHKLLS 3490 KQRKRAVVAC 3500 FRMAPLYNLP 3510 RHRSINLFLH 3520 GYQRFWIETE 3530 EYSFEEKLVQ 3540 DLAKSPKVEE 3550 EEEEETEKQP 3560 DPLHQIILYF 3570 SRNALTERSK 3580 LEDDPLYTSY 3590 SSMMAKSCQS 3600 GEDEEEDEDK 3610 EKTFEEKEME 3620 KQKTLYQQAR 3630 LHERGAAEMV 3640 LQMISASKGE 3650 MSPMVVETLK 3660 LGIAILNGGN 3670 AGVQQKMLDY 3680 LKEKKDAGFF 3690 QSLSGLMQSC 3700 SVLDLNAFER 3710 QNKAEGLGMV 3720 TEEGTLIVRE 3730 RGEKVLQNDE 3740 FTRDLFRFLQ 3750 LLCEGHNSDF 3760 QNFLRTQMGN 3770 TTTVNVIIST 3780 VDYLLRLQES 3790 ISDFYWYYSG 3800 KDIIDESGQH 3810 NFSKALAVTK 3820 QIFNSLTEYI 3830 QGPCIGNQQS 3840 LAHSRLWDAV 3850 VGFLHVFANM 3860 QMKLSQDSSQ 3870 IELLKELLDL 3880 LQDMVVMLLS 3890 LLEGNVVNGT 3900 IGKQMVDTLV 3910 ESSTNVEMIL 3920 KFFDMFLKLK 3930 DLTSSDTFKE 3940 YDPDGKGIIS 3950 KKEFQKAMEG 3960 QKQYTQSEID 3970 FLLSCAEADE 3980 NDMFNYVDFV 3990 DRFHEPAKDI 4000 GFNVAVLLTN 4010 LSEHMPNDSR 4020 LKCLLDPAES 4030 VLNYFEPYLG 4040 RIEIMGGAKK 4050 IERVYFEISE 4060 SSRTQWEKPQ 4070 VKESKRQFIF 4080 DVVNEGGEQE 4090 KMELFVNFCE 4100 DTIFEMQLAS 4110 QISESDSADR 4120 PEEEEEDEDS 4130 SYVLEIAGEE 4140 EEDGSLEPAS 4150 AFAMACASVK 4160 RNVTDFLKRA 4170 TLKNLRKQYR 4180 NVKKMTAKEL 4190 VKVLFSFFWM 4200 LFVGLFQLLF 4210 TILGGIFQIL 4220 WSTVFGGGLV 4230 EGAKNIRVTK 4240 ILGDMPDPTQ 4250 FGIHDDTMEA 4260 ERAEVMEPGI 4270 TTELVHFIKG 4280 EKGDTDIMSD 4290 LFGLHPKKEG 4300 SLKHGPEVGL 4310 GDLSEIIGKD 4320 EPPTLESTVQ 4330 KKRKAQAAEM 4340 KAANEAEGKV 4350 ESEKADMEDG 4360 EKEDKDKEEE 4370 QAEYLWTEVT 4380 KKKKRRCGQK 4390 VEKPEAFTAN 4400 FFKGLEIYQT 4410 KLLHYLARNF 4420 YNLRFLALFV 4430 AFAINFILLF 4440 YKVTEEPLEE 4450 ETEDVANLWN 4460 SFNDEEEEEA 4470 MVFFVLQEST 4480 GYMAPTLRAL 4490 AIIHTIISLV 4500 CVVGYYCLKV 4510 PLVVFKREKE 4520 IARKLEFDGL 4530 YITEQPSEDD 4540 IKGQWDRLVI 4550 NTPSFPNNYW 4560 DKFVKRKVIN 4570 KYGDLYGAER 4580 IAELLGLDKN 4590 ALDFSPVEET 4600 KAEAASLVSW 4610 LSSIDMKYHI 4620 WKLGVVFTDN 4630 SFLYLAWYTT 4640 MSVLGHYNNF 4650 FFAAHLLDIA 4660 MGFKTLRTIL 4670 SSVTHNGKQL 4680 VLTVGLLAVV 4690 VYLYTVVAFN 4700 FFRKFYNKSE 4710 DDDEPDMKCD 4720 DMMTCYLFHM 4730 YVGVRAGGGI 4740 GDEIEDPAGD 4750 PYEMYRIVFD 4760 ITFFFFVIVI 4770 LLAIIQGLII 4780 DAFGELRDQQ 4790 EQVREDMETK 4800 CFICGIGNDY 4810 FDTTPHGFET 4820 HTLQEHNLAN 4830 YLFFLMYLIN 4840 KDETEHTGQE 4850 SYVWKMYQER 4860 CWDFFPAGDC 4870 FRKQYEDQLG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034704 calcium channel complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Cellular Component GO:0005790 smooth endoplasmic reticulum
Cellular Component GO:0030018 Z disc
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0048763 calcium-induced calcium release activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0015278 intracellularly gated calcium channel activity
Molecular Function GO:0005219 ryanodine-sensitive calcium-release channel activity
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0071318 cellular response to ATP
Biological Process GO:0071313 cellular response to caffeine
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0071286 cellular response to magnesium ion
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0006941 striated muscle contraction

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.