Search Results

Overview

Uniprot IDQ15417
Protein NameCalponin-3
Gene NameCNN3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
132 LAGLAKTKGFHTTID
156 TRRFDEGKLKAGQSV
158 RFDEGKLKAGQSVIG
17 YGLSAEVKNKIASKY
172 GLQMGTNKCASQAGM
19 LSAEVKNKIASKYDH
23 VKNKIASKYDHQAEE
251 SLQMGTNKVASQKGM
256 TNKVASQKGMSVYGL
6 **MTHFNKGPSYGLS

Function

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity

Protein Sequence

10 MTHFNKGPSY 20 GLSAEVKNKI 30 ASKYDHQAEE 40 DLRNWIEEVT 50 GMSIGPNFQL 60 GLKDGIILCE 70 LINKLQPGSV 80 KKVNESSLNW 90 PQLENIGNFI 100 KAIQAYGMKP 110 HDIFEANDLF 120 ENGNMTQVQT 130 TLVALAGLAK 140 TKGFHTTIDI 150 GVKYAEKQTR 160 RFDEGKLKAG 170 QSVIGLQMGT 180 NKCASQAGMT 190 AYGTRRHLYD 200 PKMQTDKPFD 210 QTTISLQMGT 220 NKGASQAGML 230 APGTRRDIYD 240 QKLTLQPVDN 250 STISLQMGTN 260 KVASQKGMSV 270 YGLGRQVYDP 280 KYCAAPTEPV 290 IHNGSQGTGT 300 NGSEISDSDY 310 QAEYPDEYHG 320 EYQDDYPRDY QYSDQGIDY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0098641 cadherin binding involved in cell-cell adhesion
Molecular Function GO:0005516 calmodulin binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0030855 epithelial cell differentiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.